Marine Skeletal Biopolymers and Proteins and Their Biomedical Application

Rahman, M. Azizur

doi:10.3390/md19070389

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…At the same time, our data support both systematics and phylogenetic analyses together with marine collagen applied research. Indeed, collagenic sponge material was proved to enhance for example drug delivery (Langasco et al, 2017; Rahman, 2021; Swatschek et al, 2002) and to promote bone mineralization (Granito et al, 2017; Green et al, 2003; Kim et al, 2009). Soft body sponges are confirmed as versatile and multifaceted source of bioinspired materials.…”

Section: Discussionmentioning

confidence: 99%

Collagenic architecture and morphotraits in a marine basal metazoan as a model for bioinspired applied research

Manconi

Cubeddu

Pronzato

et al. 2022

Journal of Morphology

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In some Porifera (Demospongiae: Keratosa), prototypes of the connective system are almost exclusively based on collagenic networks. We studied the topographic distribution, spatial layout, microtraits, and/or morphogenesis of these collagenic structures in Ircinia retidermata (Dictyoceratida: Irciniidae). Analyses were carried out on a clonal strain from sustainable experimental mariculture by using light and scanning electron microscopy. Histology revealed new insights on the widely diversified and complex hierarchical assemblage of collagenic structures. Key evolutionary novelties in the organization of sponge connective system were found out. The aquiferous canals are shaped as corrugate‐like pipelines conferring plasticity to the water circulation system. Compact clusters of elongated cells are putatively involved in a nutrient transferring system. Knob‐ended filaments are characterized by a banding pattern and micro‐components. Ectosome and outer endosome districts are the active fibrogenetic areas, where exogenous material constitutes an axial condensation nucleus for the ensuing morphogenesis. The new data can be useful to understand not only the evolutionary novelties occurring in the target taxon but also the morpho‐functional significance of its adaptive collagenic anatomical traits. In addition, data may give insights on both marine collagen sustainable applied researches along with evolutionary and phylogenetic analyses, thus highlighting sponges as a key renewable source for inspired biomaterials. Therefore, we also promote bioresources sustainable exploitation with the aim to provide new donors of marine collagen, thereby supporting conservation of wild populations/species.

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Section: Discussionmentioning

confidence: 99%

Collagenic architecture and morphotraits in a marine basal metazoan as a model for bioinspired applied research

Manconi

Cubeddu

Pronzato

et al. 2022

Journal of Morphology

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“…The anticancer properties of marine biopolymers deserve special attention. The US FDA has approved many essential cancer medicines derived from marine sources, including cytarabine and ticlopidine [ 172 ].…”

Section: Natural Polymersmentioning

confidence: 99%

Smart Polymeric Nanoparticles in Cancer Immunotherapy

Shen

et al. 2023

Pharmaceutics

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Cancer develops with unexpected mutations and causes death in many patients. Among the different cancer treatment strategies, immunotherapy is promising with the benefits of high specificity and accuracy, as well as modulating immune responses. Nanomaterials can be used to formulate drug delivery carriers for targeted cancer therapy. Polymeric nanoparticles used in the clinic are biocompatible and have excellent stability. They have the potential to improve therapeutic effects while significantly reducing off-target toxicity. This review classifies smart drug delivery systems based on their components. Synthetic smart polymers used in the pharmaceutical industry, including enzyme-responsive, pH-responsive, and redox-responsive polymers, are discussed. Natural polymers derived from plants, animals, microbes, and marine organisms can also be used to construct stimuli-responsive delivery systems with excellent biocompatibility, low toxicity, and biodegradability. The applications of smart or stimuli-responsive polymers in cancer immunotherapies are discussed in this systemic review. We summarize different delivery strategies and mechanisms that can be used in cancer immunotherapy and give examples of each case.

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Natural biopolymers combined with metallic nanoparticles: a view of biocompatibility and cytotoxicity

Soto-Mendoza,

Larrañaga-Tapia,

Robles

et al. 2023

Handbook of Natural Polymers, Volume 1

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Marine Skeletal Biopolymers and Proteins and Their Biomedical Application

Abstract: Skeletal biopolymers and proteins in marine organisms are present as complex mixtures and have great potential applications in the biomedical field [...]

Cited by 4 publications

References 26 publications

Collagenic architecture and morphotraits in a marine basal metazoan as a model for bioinspired applied research

Collagenic architecture and morphotraits in a marine basal metazoan as a model for bioinspired applied research

Smart Polymeric Nanoparticles in Cancer Immunotherapy

Natural biopolymers combined with metallic nanoparticles: a view of biocompatibility and cytotoxicity

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