Background: Injury due to war or accidents causes numerous mental, physical, and social adverse effects on affected individuals and their family. Aims: This study was conducted to determine the effectiveness of life skills training on happiness, mental health, and marital satisfaction in wives of Iran-Iraq war veterans. Methods and Material: In this semi experimental, controlled study with pretest-posttest, 102 veterans in Shahrekord, southwest Iran were randomly assigned to two groups, intervention and control, after they filled out a written consent form. The intervention group alone received training on four domains of life skills, coping with stress, problem solving, decision-making, and communication skills, for eight weeks. Oxford Happiness Questionnaire, General Health Questionnaire (GHQ-28), and ENRICH Marital Satisfaction Scale were administered at three steps, before intervention, immediately after intervention, and six months after intervention (as follow-up). The data were analyzed by analysis of covariance in SPSS 23. Results: The mean scores of happiness and mental health indicated a significant difference between the two groups at posttest (P<001). But in follow-up, the difference was significant for neither of the variables (P>0.05). Mean scores of marital satisfaction exhibited significant difference at both posttest (P<001) and follow-up (P=0.001) between the two groups. Conclusion: Life skills training for veterans' wives can help them promote their mental, physical health, and marital satisfaction, but the findings on follow-up indicate that this effect is not lasting. Therefore, life skills training should be done continuously particularly to promote mental health and happiness.