Marital status, education, and income in relation to the risk of esophageal and gastric cancer by histological type and site

Lagergren, Jesper; Andersson, Gunnar; Talbäck, Mats; Drefahl, Sven; Bihagen, Erik; Härkönen, Juho; Feychting, Maria; Ljung, Rickard

doi:10.1002/cncr.29731

Cited by 73 publications

(58 citation statements)

References 21 publications

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“…However, other studies reported no significant correlation between county-level income and survival [45] or an association only for patients with early stage disease [46]. Higher education level at the community level has also been identified as having a positive influence on survival [42, 47]; however, our analysis did not show that county-level economic status or education was significant independent prognostic factors. Finally, several studies found that race influenced prognosis for certain types of cancer (e.g., lung, liver, breast, and prostate) [48], whereas other studies found that the effect was minimal after adjusting for other socioeconomic factors [49], which is consistent with our results.…”

Section: Discussioncontrasting

confidence: 89%

“…Although most studies suggested that personal income is related to cancer survival [41, 42], the impact of the regional economic environment (e.g., county-level median household income) remains controversial. Higher neighborhood income level has been associated with higher survival rates, which can be partially explained by differences in disease stage at presentation, first-line treatment, and comorbidities [41, 43, 44].…”

Section: Discussionmentioning

confidence: 99%

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Marital status is an independent prognostic factor for tracheal cancer patients: an analysis of the SEER database

Dai

Wang²,

Chen

et al. 2016

Oncotarget

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BackgroundAlthough marital status is an independent prognostic factor in many cancers, its prognostic impact on tracheal cancer has not yet been determined. The goal of this study was to examine the relationship between marital status and survival in patients with tracheal cancer.ResultsCompared with unmarried patients (42.67%), married patients (57.33%) had better 5-year OS (25.64% vs. 35.89%, p = 0.009) and 5-year TCSS (44.58% vs. 58.75%, p = 0.004). Results of multivariate analysis indicated that marital status is an independent prognostic factor, with married patients showing better OS (hazard ratio [HR] = 0.78, 95% confidence interval [CI] 0.64–0.95, p = 0.015) and TCSS (HR = 0.70, 95% CI 0.54–0.91, p = 0.008). In addition, subgroup analysis suggested that marital status plays a more important role in the TCSS of patients with non-low-grade malignant tumors (HR = 0.71, 95% CI 0.53–0.93, p = 0.015).MethodsWe extracted 600 cases from the Surveillance, Epidemiology, and End Results (SEER) database. Variables were compared by Pearson chi-squared test, t-test, log-rank test, and multivariate Cox regression analysis. Overall survival (OS) and tracheal cancer-specific survival (TCSS) were compared between subgroups with different pathologic features and tumor stages.ConclusionsMarital status is an independent prognostic factor for survival in patients with tracheal cancer. For that reason, additional social support may be needed for unmarried patients, especially those with non-low-grade malignant tumors.

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Section: Discussioncontrasting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Marital status is an independent prognostic factor for tracheal cancer patients: an analysis of the SEER database

Dai

Wang²,

Chen

et al. 2016

Oncotarget

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“…The results were similar with previous researches investigating the associations between marital status and survival in breast, lung, colorectal, esophageal, and gastric cancers. 22, 23, 24, 25. While the mechanism underlying the improved survival associated with marriage in patients is not entirely clear, with the analyses from this study, the possible reasons for the unfavorable prognosis of unmarried patients, especially for widowed or divorced ones, are proposed as follows.…”

Section: Discussionmentioning

confidence: 81%

The impact of marital status at diagnosis on cancer survival in patients with differentiated thyroid cancer

Shi

Lü

et al. 2016

Cancer Medicine

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Previous studies have revealed that marital status influences the prognosis of patients with various types of cancer. We evaluated the influence of marriage on the survival outcomes in differentiated thyroid cancer (DTC). The Surveillance, Epidemiology and End Results (SEER) database between 2002 and 2012 was used to compare cancer‐specific mortality in different marital status, and in each sex, age, and stage stratification by multivariate Cox regression model. In total, 61,077 eligible patients were identified. The widowed group had the highest proportion of women, elderly patients (≥45 years), and advanced stage III/IV tumor (P = 0.001), but the total thyroidectomy (TT) performed and radioisotopes therapy rates were lower than those in the married group. Married patients had a better cancer‐specific survival (CSS) than the unmarried (P < 0.05). Further analysis showed that widowed patients always presented the lowest CSS compared with other groups. Widowed patients had a significant increased risk for CSS compared with married patients in males [hazard ratio (HR) 2.72, 95% confidence interval (CI): 1.59–4.65, P = 0.001], females (HR 2.02, 95% CI: 2.24–4.06, P = 0.001), young patients (<45, HR 28.12, 95% CI: 3.48–227.25, P = 0.002), elderly patients (≥45, HR 28.12, 95% CI: 2.97, 95% CI: 2.30–3.83, P = 0.001), stage I (HR 8.44, 95% CI: 4.05–17.59, P = 0.001), stage II (HR 3.64, 95% CI: 1.30–10.20, P = 0.014), stage III (HR 2.27, 95% CI: 1.08–4.78, P = 0.031), and stage IV (HR 2.63, 95% CI: 1.94–3.57, P = 0.001). These results showed that unmarried status, especially for widowhood, increased the risk of cancer mortality in DTC patients.

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“…Moreover, it is the third leading cause of cancer-related death in both sexes worldwide [1]; in 2011, it accounted for 4% of cancer death [2]. The distribution of gastric cancer varies across geographical regions, which illustrates the multitude of factors that are associated with the incidence, survival, and mortality rates of the disease [3]; even marital status, low educational attainment, and low income increase the risk of gastric cancer [4]. In 2012, 70% of gastric cancer cases occurred in developing countries, and about half of them occurred in eastern Asia [35].…”

Section: Introductionmentioning

confidence: 99%

Analysis ofG3BP1andVEZTExpression in Gastric Cancer and Their Possible Correlation with Tumor Clinicopathological Factors

Beheshtizadeh

Moslemi

2017

J Gastric Cancer

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PurposeThis study aimed to analyze G3BP1 and VEZT expression profiles in patients with gastric cancer, and examine the possible relationship between the expressions of each gene and clinicopathological factors.Materials and MethodsExpression of these genes in formalin-fixed paraffin embedded (FFPE) tissues, collected from 40 patients with gastric cancer and 40 healthy controls, was analyzed. Differences in gene expression among patient and normal samples were identified using the GraphPad Prism 5 software. For the analysis of real-time polymerase chain reaction products, GelQuantNET software was used.ResultsOur findings demonstrated that both VEZT and G3BP1 mRNA expression levels were downregulated in gastric cancer samples compared with those in the normal controls. No significant relationship was found between the expression of these genes and gender (P-value, 0.4835 vs. 0.6350), but there were significant changes associated with age (P-value, 0.0004 vs. 0.0001) and stage of disease (P-value, 0.0019 vs. 0.0001). In addition, there was a direct relationship between VEZT gene expression and metastasis (P-value, 0.0462), in contrast to G3BP1 that did not demonstrate any significant correlation (P-value, 0.1833).ConclusionsThe results suggest that expression profiling of VEZT and G3BP1 can be used for diagnosis of gastric cancer, and specifically, VEZT gene could be considered as a biomarker for the detection of gastric cancer progression.

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Marital status, education, and income in relation to the risk of esophageal and gastric cancer by histological type and site

Abstract: Divorce, widowhood, living alone, low educational attainment, and low income increase the risk of each subtype of esophageal and gastric cancer. These associations require attention when high-risk individuals are being identified. Cancer 2016;122:207-212. © 2015 American Cancer Society.

Cited by 73 publications

References 21 publications

Marital status is an independent prognostic factor for tracheal cancer patients: an analysis of the SEER database

Marital status is an independent prognostic factor for tracheal cancer patients: an analysis of the SEER database

The impact of marital status at diagnosis on cancer survival in patients with differentiated thyroid cancer

Analysis ofG3BP1andVEZTExpression in Gastric Cancer and Their Possible Correlation with Tumor Clinicopathological Factors

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