Marital status is associated with superior survival in patients with esophageal cancer: a Surveillance, Epidemiology, and End Results study

Du, Lijun; Kim, John J.; Chen, Binrui; Zhu, Shuwen; Dai, Ning

doi:10.18632/oncotarget.21609

Cited by 22 publications

(28 citation statements)

References 25 publications

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“…A Swedish study demonstrated that unmarried patients diagnosed of gastric cancer or esophageal cancer had poorer survival compared with the married patients 6 . Two recent population-based studies also found that marital status was associated with superior survival in patients with esophageal cancer (EC) 7 - 8 . On the contrary, Brusselaers N et al showed no evidence of a better 5-year survival in married patients with EC who received surgery 9 .…”

Section: Discussionmentioning

confidence: 98%

A nomogram to predict long-time survival for patients with M1 diseases of esophageal cancer

et al. 2018

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Objective: To evaluate the clinicopathologic characteristics of the long-time survivals and construct a clinical nomogram using the Surveilance, Epidemiology, and End Results (SEER) database.Materials and Methods: Information of patients diagnosed with M1 stage esophageal cancer from 2010-2014 was retrieved from SEER database. Patients with unknown information of AJCC TNM stage or metastatic sites or marital status or surgery or survival were excluded. Demographic and clinicopathologic characteristics were compared between LTS (long time survivals: patients who have survived for no less than 2 years) and STS (shorter time survivals: patients who have survived for less than 2 years). Cox regression analysis was performed to evaluate prognostic factors. A nomogram comprising demographic and clinicopathologic factors was established to predict 1-year survival and 2-year survival for patients with M1 diseases.Results: A total of 2981 patients from the SEER database were included for analysis. Compared with the STS, married people and patients with well differentiated tumors or oligometastatic site were more likely to be LTS. Also, LTS were associated with significantly less bone metastasis and more surgery. The OS nomogram, which had a c-index of 0.633, was based on the eleven variables: gender, age, marital status, T stage, N stage, histology, grade, number of important metastatic organs and primary surgery.Conclusions: Married patients, patients with well differentiated tumors, patients with oligometastatic site, patients without bone metastasis or liver metastasis and those who underwent surgery are associated with long time survivals. We developed a nomogram predicting 1- and 2-year OS and CSS for M1 stage esophageal cancer. The prognostic model may improve clinicians' abilities to predict individualized survival and to make treatment recommendations.

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Section: Discussionmentioning

confidence: 98%

A nomogram to predict long-time survival for patients with M1 diseases of esophageal cancer

et al. 2018

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“…Interestingly, we found that single patients tend to have lower risks of developing SPMs (Table 1), which is likely due to the fact that single patients had worse survival outcomes than married patients. [26] For tumor location, the different risks were likely related to different surgical difficulties; for example, upper thoracic esophageal cancer is more difficult to resect than lower esophageal cancer. Currently, there is much controversy related to procedural complexity.…”

Section: Discussionmentioning

confidence: 99%

Second primary malignancy in patients with esophageal adenocarcinoma and squamous cell carcinoma

Zhang

Wu²,

Wang³

et al. 2019

Medicine

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“…7 It is important to note that the Swedish study only compared patients who had received esophagectomy, whereas the other studies compared all patients with esophageal cancer. [4][5][6] These results may imply that differences in survival between married and unmarried patients may be a result of receipt of treatment. Similarly, studies have found associations between lower use of esophagectomy in Black patients and racial disparities in esophageal cancer outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…Prior studies have found associations between marital status and esophageal cancer survival. [4][5][6] Using the SEER database, 2 separate studies found that married patients had higher overall and cancer-specific survival than unmarried patients. 5,6 In contrast, a prospective population-based cohort study from Sweden found no significant differences in 5-year survival between married and unmarried patients.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6] Using the SEER database, 2 separate studies found that married patients had higher overall and cancer-specific survival than unmarried patients. 5,6 In contrast, a prospective population-based cohort study from Sweden found no significant differences in 5-year survival between married and unmarried patients. 7 It is important to note that the Swedish study only compared patients who had received esophagectomy, whereas the other studies compared all patients with esophageal cancer.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Marital Status and Racial Disparities in Esophageal Cancer Care

Cruz

Haug

Zhao

et al. 2020

JCO Oncology Practice

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PURPOSE: This study was designed to examine the impact of marital status on racial disparities in esophageal cancer care. PATIENTS AND METHODS: We performed a secondary analysis of data collected from the state cancer registry maintained by the Michigan Department of Health and Human Services. We identified patients with an esophageal cancer diagnosis between January 1, 2000, and December 31, 2013. χ2 test and logistics regression were used to analyze 6,809 patients who met our eligibility criteria. Statistical significance was defined as P ≤ .05. RESULTS: Approximately 88.4% of our patients were White and 11.6% were Black. A significantly higher number of White patients were married when compared with Blacks (62.9% v 31.8%, respectively; P < .0001). There was no significant difference in cancer staging between the 2 groups ( P = .0671). Married Blacks had similar rates of esophagectomy, chemotherapy, and radiation as married Whites. Both single groups had lower rates of esophagectomy and chemotherapy than married Whites, but single Blacks were the least likely to undergo esophagectomy. Single patients were more likely to refuse treatment. CONCLUSION: Marital status differs significantly in Black and White patients with esophageal cancer and may help explain racial disparities in cancer care. Further research is needed to explore reasons for care underutilization in single patients and whether these differences translate into clinical outcomes.

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Marital status is associated with superior survival in patients with esophageal cancer: a Surveillance, Epidemiology, and End Results study

Cited by 22 publications

References 25 publications

A nomogram to predict long-time survival for patients with M1 diseases of esophageal cancer

A nomogram to predict long-time survival for patients with M1 diseases of esophageal cancer

Second primary malignancy in patients with esophageal adenocarcinoma and squamous cell carcinoma

Association Between Marital Status and Racial Disparities in Esophageal Cancer Care

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