Marked effect of DNA on collagen fibrillogenesis in vitro

Kitamura, Hiroyuki; Iwamoto, Chiaki; Sakairi, Nobuo; Tokura, Seiichi; Nishi, Norio

doi:10.1016/s0141-8130(97)00021-4

Cited by 40 publications

(26 citation statements)

References 12 publications

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“…Accordingly it is very important study the principles of organization of the molecular complex between collagen and DNA. As demonstrated in [3,4] growth of collagen fibrils in the presence of DNA was more rapid than in the absence of DNA. These results suggest that DNA not only absorbs to collagen but induces the extraordinary fibrillogenesis of collagen.…”

mentioning

confidence: 86%

DNA as a matrix of collagen fibrils

Mrevlishvili

Svintradze

2005

International Journal of Biological Macromolecules

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mentioning

confidence: 86%

DNA as a matrix of collagen fibrils

Mrevlishvili

Svintradze

2005

International Journal of Biological Macromolecules

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“…At the body level, these cell deaths may increase the mutations and cancer risks by altering metabolism or damaging normal tissue. As a result, many organic aromatic compounds such as PCB, dioxin and dyes have been considered as mutagens or carcinogens [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Gelation of Dna and Bovine Serum Albumin (Dna-Bsa Gel) by Gamma Irradiation as Bio-Absorbent for Acridine Orange

Saito¹,

Quynh²,

Furusawa³

et al. 2016

RAD Conference Proceedings

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Abstract. Together with their advantages, the availability of synthetic organic chemicals also caused many adverse effects to the environment due to the fact that they do not seem to be completely bio-degraded in nature. The residues of these synthetic organic compounds, such as polychlorinated biphenyl (PCBs), acridine orange (AO) and other aromatics, as well as their degraded intermediates, may become carcinogens or mutagens, which severely affect human health. In the cell, these organic compounds can intercalate into the major grooves and interstices between the base pair of DNA double helix, resulting in several diseases and cancers. In other words, DNA can be utilized as the most efficient bio-adsorbent of such toxic agents. For this purpose, DNA must be in water-insoluble state. Recently, radiation has been proven to be one of the effective methods of introducing the crosslinking network in the polymer matrix. Though DNA is easily broken by radiation, it can crosslink in the presence of suitable crosslinkers, or be immobilized onto the crosslinking gels. In this study, we have successfully prepared DNA/BSA complex gels from aqueous mixtures of DNA with BSA by gamma irradiation. Their gelation behaviors were characterized for utilization as adsorbents for AO. The results indicated that the adsorption was a time-dependent process and the adsorption capacity of AO increased with DNA amount in the DNA/BSA gels.

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“…Previously, we reported that collagen binds to DNA originating from salmon milt (DNA salmon ) and forms a complex [23][24][25]. The collagen-DNA salmon complex formed straight fibrils with a clear cross-banding pattern ascertained by TEM observations even when using atelocollagen, although the atelocollagen without telopeptides has been considered to form thin fibrils without a clear cross-banding pattern.…”

Section: Introductionmentioning

confidence: 99%