Marked elevation of myocardial trace elements in idiopathic dilated cardiomyopathy compared with secondary cardiac dysfunction

Frustaci, Andrea; Magnavita, Nicola; Chimenti, Cristina; Caldarulo, Marina; Sabbioni, E.; Pietra, R.; Cellini, Carlo; Possati, Gianfederico; Maseri, Attilio

doi:10.1016/s0735-1097(99)00062-5

Cited by 94 publications

(59 citation statements)

References 25 publications

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“…As an example, a recent report on trace elements in idiopathic dilated cardiomyopathy (IDCM) showed an increase of > 10,000 times more mercury in myocardial tissue than in skeletal muscle in all patients with this condition. The mean mercury level in cardiac muscle was 22,000 times higher in IDCM patients than in control subjects (178.4 µg/g vs. 0.008 µg/g; Frustaci et al 1999).…”

Section: Discussionmentioning

confidence: 85%

Mercury levels in high-end consumers of fish.

Hightower

Moore

2003

Environ Health Perspect

305

138

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Consumption of food containing mercury has been identified as a health risk. The U.S. Environmental Protection Agency (U.S. EPA) and the National Academy of Sciences recommend keeping the whole blood mercury level < 5.0 microg/L or the hair level < 1.0 microg/g. This corresponds to a reference dose (RfD) of 0.1 microg/kg body weight per day. All patients in a 1-year period (n = 720) who came for an office visit in a private internal medicine practice in San Francisco, California, were evaluated for mercury excess using the current RfD. One hundred twenty-three patients were tested (93 females, 30 males). Of these, data were statistically analyzed for 89 subjects. Mercury levels ranged from 2.0 to 89.5 microg/L for the 89 subjects. The mean for 66 women was 15 microg/L [standard deviation (SD) = 15], and for 23 men was 13 microg/L (SD = 5); 89% had levels exceeding the RfD. Subjects consumed 30 different forms or types of fish. Swordfish had the highest correlation with mercury level. Sixty-seven patients with serial blood levels over time after stopping fish showed a decline in mercury levels; reduction was significant (p < 0.0001). A substantial fraction of patients had diets high in fish consumption; of these, a high proportion had blood mercury levels exceeding the maximum level recommended by the U.S. EPA and National Academy of Sciences. The mean level for women in this survey was 10 times that of mercury levels found in a recent population survey by the U.S. Centers for Disease Control and Prevention. Some children were > 40 times the national mean.

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Section: Discussionmentioning

confidence: 85%

Mercury levels in high-end consumers of fish.

Hightower

Moore

2003

Environ Health Perspect

305

138

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“…It has been suggested that it may play a role in the pathogenesis of many cardiovascular diseases such as arteriosclerosis, idiopathic dilated cardiomyopathy and hypertension [21][22][23] . In a recent epidemiologic study, it has been reported that chronic Cd exposure may have increased the blood pressure and the risk of hypertension in the general adult Korean population [24] .…”

Section: Discussionmentioning

confidence: 99%

The Effect of Chronic Cadmium Toxicity on Blood Pressure and Plasma Viscosity

Koçak

Yazıhan²,

Akçıl

et al. 2010

Pathophysiol Haemos Thromb

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Cadmium (Cd) is a heavy metal which affects many systems in humans and animals as a consequence of environmental and industrial pollution. The aim of this study was to investigate the effect of chronic Cd toxicity on blood pressure and plasma viscosity. Experimental group rats were given doses that contained 15 ppm CdCl₂ in drinking water for 8 weeks. The systolic blood pressure and heart rate were measured from rats’ tails and recorded by plethysmography every two weeks. Blood samples were drawn, Cd levels were determined by atomic absorption spectrophotometer and plasma viscosity values by viscometer. Blood Cd levels were found to be significantly higher in the experimental group compared to the control group (p < 0.001). The whole blood analysis was made by an analyzer. Polymorphonuclear leukocytes and monocytes increased (p < 0.01) and lymphocyte number (p < 0.05) decreased in the experimental group. Viscosity values were 2.21 ± 0.54 and 1.62 ± 0.31 centipoises in the experimental and control groups, respectively (p < 0.001). In the experimental group, changes in systolic blood pressure between weeks were significant (p < 0.001) and were found to be correlated with plasma viscosity (p < 0.001). In the experimental group, changes in heart rate between weeks were significant (p < 0.001). According to our findings, Cd toxicity may lead to an increase in blood pressure by increasing plasma viscosity.

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“…[31] Baz› kalp yetersizli¤i olgular›nda kalp dokusunda önemli miktarda (kontrollerin 22.000 kat›) c›va birikimi saptanm›flt›r. [32] 5-7 y›l süren insan çal›flmalar›nda amalgam dolgular›n böbrek fonksiyonlar›na etkisine dair hiçbir kan›t bulunamam›flt›r, [33] ne var ki, tam tersi sonuçlara ulaflan ça-l›flmalar da mevcuttur. [34] Hayvan deneylerinde, amalgam dolgu nedeniyle böbrek fonksiyonlar›n›n bozuldu¤u gö-rülmüfltür.…”

Section: Discussionunclassified

Effects of amalgam fillings on human tissues

Akgün¹

2012

Turk Aile Hek Derg

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Marked elevation of myocardial trace elements in idiopathic dilated cardiomyopathy compared with secondary cardiac dysfunction

Abstract: A large, significant increase of myocardial TE is present in IDCM but not in secondary cardiac dysfunction. The increased concentration of TE in pts with IDCM may adversely affect mitochondrial activity and myocardial metabolism and worsen cellular function.

Cited by 94 publications

References 25 publications

Mercury levels in high-end consumers of fish.

Mercury levels in high-end consumers of fish.

The Effect of Chronic Cadmium Toxicity on Blood Pressure and Plasma Viscosity

Effects of amalgam fillings on human tissues

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