Marked Elevation of Serum CA19-9 and Stomach Carcinoma

Horie, Yutaka; Matsui, Katsuaki; Shigoku, Azusa; Yukimasa, Akira; Miura, Kunihiko; Hosoda, Asao; Hamamoto, Tetsuro; Kawasaki, Hironaka

doi:10.1159/000011900

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…25 Significant correlations between sLe a parameters and hematogenous metastasis were confirmed by Nakayama et al 32 In comparison with findings for carcinoembryonic antigen (CEA), marked elevation of serum sLe a was reported to be associated with moderately differentiated stomach carcinoma. 33 Alvarez et al 34 proposed the simultaneous determination of CEA, tissue polypeptide antigen (TPA), and sLe a in the diagnosis of colorectal adenocarcinoma. They confirmed that sLe a was the most sensitive tumor marker and that combined determination with sLe a and CEA provided 100% sensitivity in Dukes' stage D tumors.…”

Section: Discussionmentioning

confidence: 99%

Paired tumor marker of soluble E-selectin and its ligand sialyl Lewis A in colorectal cancer

Ito

Hibi

et al. 2001

Journal of Gastroenterology

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Section: Discussionmentioning

confidence: 99%

Paired tumor marker of soluble E-selectin and its ligand sialyl Lewis A in colorectal cancer

Ito

Hibi

et al. 2001

Journal of Gastroenterology

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Exercise, Cachexia, and Cancer Therapy: A Molecular Rationale

Ardies¹

2002

Nutrition and Cancer

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Evidence from recent publications indicates that repeated exercise may enhance the quality of life of cancer patients. The lack of reported negative effects and the consistency of the observed benefits lead one to conclude that physical exercise may provide a low-risk therapy that can improve patients' capacity to perform activities of daily living and improve their quality of life. Repeated physical activity may attenuate the adverse effects of cancer therapy, prevent or reverse cachexia, and reduce risk for a second cancer through suppression of inflammatory responses or enhancement of insulin sensitivity, rates of protein synthesis, and anti-oxidant and phase II enzyme activities. These results most likely come about through the ability of physical exercise to attenuate a chronic inflammatory signaling process and to transiently activate the mitogen-activated protein kinase, c-Jun NH2-terminal kinase, c-Jun NH2-terminal kinase-mitogen-activated protein kinase, and nuclear factor-kappa B pathways and through its ability to enhance insulin sensitivity. Expanded molecular-based research into these areas may provide new insights into the biological mechanisms associated with cancer rehabilitation and endogenous risk.

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Effects of Green Tea and High-Fat Diet on Arachidonic Acid Metabolism and Aberrant Crypt Foci Formation in an Azoxymethane-Induced Colon Carcinogenesis Mouse Model

Ju¹,

Liu²,

Hong³

et al. 2003

Nutrition and Cancer

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Excessive fat consumption is a risk factor for colon carcinogenesis, and green tea consumption may reduce the risk of colon and other cancers. The current study was designed to investigate the effects of green tea and a high-fat diet on arachidonic acid metabolism and aberrant crypt foci formation in an azoxymethane (AOM)-induced colon carcinogenesis mouse model. We also determined whether green tea consumption altered the size of regional fat pads. CF-1 female mice were maintained on either a high-fat (20% corn oil) or a low-fat (5% corn oil) diet. AOM was given subcutaneous at a dose of 7.5 mg/kg body weight at 6 wk and then a dose of 10 mg/kg at 7 wk of age. Two weeks after the second AOM injection, 0.6% green tea (6 mg tea solids/ml) was given as the drinking fluid and continued for 10 wk until the experiment was terminated. In the AOM-treated mice not receiving green tea, the high-fat diet significantly enhanced colonic levels of 5-lipoxygenase, leukotriene A4 hydrolase, and leukotriene B4, but it did not significantly alter prostaglandin E2 levels and aberrant crypt foci formation. In AOM-treated mice on the high-fat diet, green tea significantly decreased colonic levels of cytosolic phospholipase A2, 5-lipoxygenase, and leukotriene B4; green tea treatment also decreased the number of aberrant crypt foci (P < 0.05). The weights of parametrial and retroperitoneal fat pads were increased by the high-fat diet and decreased by green tea treatment. The current results indicate that green tea consumption and dietary fat modulate 5-lipoxygenase-dependent pathway of arachidonic acid metabolism during AOM-induced colon carcinogenesis. Green tea inhibits ACF formation in mice on a high corn oil diet, suggesting its possible inhibitory effect on colon carcinogenesis in populations such as those in Western countries that consume high amounts of fat.

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Marked Elevation of Serum CA19-9 and Stomach Carcinoma

Cited by 4 publications

References 3 publications

Paired tumor marker of soluble E-selectin and its ligand sialyl Lewis A in colorectal cancer

Paired tumor marker of soluble E-selectin and its ligand sialyl Lewis A in colorectal cancer

Exercise, Cachexia, and Cancer Therapy: A Molecular Rationale

Effects of Green Tea and High-Fat Diet on Arachidonic Acid Metabolism and Aberrant Crypt Foci Formation in an Azoxymethane-Induced Colon Carcinogenesis Mouse Model

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