Marked increase in serum CA 19-9 level in patients with alcoholic cirrhosis: report of four cases

Mathurin, Philippe; Cadranel, Jean–François; Bouraya, Dalila; Bronstein, Jean‐Ariel; Collot, Gerard; Devergie, B; Poynard, Thierry; Opolon, P

doi:10.1097/00042737-199611000-00019

Cited by 12 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are in agreement with findings reported from the Mayo Clinic (24) and others (25). We also found high CA 19-9 serum levels in patients with alcoholic liver cirrhosis (median 92, range 70-121 ng/ml) similar to previous studies (22,(26)(27)(28) and, in one study, of all chronic liver diseases, alcoholic liver disease was associated with the highest frequency of abnormal CA 19-9 values, with as many as 73% of patients with values higher than the upper reference value (22).…”

Section: Discussionsupporting

confidence: 93%

CA 19–9 and CE A are unreliable markers for cholangiocarcinoma in patients with primary sclerosing cholangitis

Bjõrnsson

Kilander

Olsson

1999

Liver

139

View full text Add to dashboard Cite

Tumor markers as a diagnostic tool in diagnosing CC in patients with PSC are unfortunately not as valuable as previously reported. The serum levels of CA 19-9 can rise temporarily in association with a "biochemical relapse" of PSC (increased values of serum alkaline phosphatase). The marker product of CA 19-9 and CEA has a low sensitivity but a relatively high specificity for the detection of CC in PSC patients.

show abstract

Section: Discussionsupporting

confidence: 93%

CA 19–9 and CE A are unreliable markers for cholangiocarcinoma in patients with primary sclerosing cholangitis

Bjõrnsson

Kilander

Olsson

1999

Liver

139

View full text Add to dashboard Cite

show abstract

“…Elevated serum CEA level has been ascertained in various benign gastrointestinal and hepatic conditions such as pancreatitis, cholecystitis, and peptic ulcer disease [42,43]; smoking and age may also affect the results of serum CEA measurement [20]. CA 19-9 levels can be very high in acute cholangitis, chronic hepatitis, and liver cirrhosis [44][45][46], and the use of drugs such as colchicine and Ganoderma lucidum spore powder (GLSP) may cause abnormal elevation of serum CA72-4 [47,48]. In this study, we excluded some patients with serious complications and adjusted the patient's age, smoking, and other factors, but we could not adjust all the factors that may affect the level of tumor markers currently known.…”

Section: Discussionmentioning

confidence: 99%

The Number of Positive Tumor Markers (NPTM) Achieves Higher Value in the Prognosis Prediction of Gastric Cancer

Liu

et al. 2022

Disease Markers

View full text Add to dashboard Cite

Purpose. The clinical application of combined tumor markers is still limited. We aim to explore the value of the combination of multiple tumor markers in gastric cancer (GC) prognosis. Methods. The prognostic significance was evaluated using Kaplan–Meier log-rank survival analysis and multivariable Cox regression analysis. The estimated area under the curve (AUC) was compared to evaluate the discriminatory ability of different indicators. A nomogram was constructed based on the results of multivariable cox regression, and its performance was evaluated by Harrell’s concordance index and calibration curve. Results. NPTM (number of positive tumor markers) displayed independent prognostic significance whether in the whole cohort or in patients with different stages. Patients with the all-negative tumor markers had a worse prognosis after postoperative chemotherapy in all cohort ( P = 0.023 ) or in age ≤60 subgroup ( P = 0.012 ), while patients with positive tumor markers had a better prognosis after postoperative chemotherapy in stage III ( P = 0.012 ). The AUC value of NPTM is higher than any individual tumor marker. The 1-, 3-, and 5-year AUC values of the CTNM (combination of NPTM and pTNM) increased by 5%, 4.8%, and 3.6%, respectively, compared with TNM staging system. The nomogram constructed including NPTM showed its high accuracy ( C − index = 0.706 ) versus TNM staging system ( C − index = 0.646 ) and CTNM ( C − index = 0.681 ). Conclusions. NPTM was an independent predictor of gastric cancer prognosis, showing more accurate prognostic performance than individual tumor markers. Especially its significance in guiding postoperative adjuvant chemotherapy regimens and predicting prognosis by combination with TNM staging system may have a better clinical application value.

show abstract

“…In all cases, no evidence of malignancy was observed. In 1996, the European Journal of Gastroenterology and Hepatology published four unique cases with patients who had markedly elevated CA19-9 levels and 2 patients with levels above >1000 which was due to alcoholic biopsy proven cirrhosis with no concomitant pancreatic disease [2]. A German case report presents a 58-year-old male who presented with jaundice and weight loss.…”

Section: Discussionmentioning

confidence: 99%

Mirrizi Syndrome and Markedly Elevated Levels of Carbohydrate Antigen 19-9 in the Absence of Malignant Disease

Shah

Tetangco

Arshad

et al. 2017

Case Reports in Gastrointestinal Medicine

View full text Add to dashboard Cite

Elevated carbohydrate antigen 19-9 (CA19-9) beyond 1000 U/L occurs in nonneoplastic conditions which is causing questioning of the use of CA19-9 as a marker for screening. We report a case where a 51-year-old male with Mirrizi Syndrome (MS) presented with markedly increased CA19-9 level (4,618 U/mL). MS is a rare complication characterized by compression of the common bile or hepatic duct caused by an impacted gallstone in the cystic duct or neck of the gallbladder. Biliary epithelial cells secrete CA19-9: it is hypothesized that increased proliferation of such cells caused by inflammation leads to increased secretion. CA19-9 should not be used as a diagnostic tool, but rather for surveillance.

show abstract

Marked increase in serum CA 19-9 level in patients with alcoholic cirrhosis: report of four cases

Cited by 12 publications

References 0 publications

CA 19–9 and CE A are unreliable markers for cholangiocarcinoma in patients with primary sclerosing cholangitis

CA 19–9 and CE A are unreliable markers for cholangiocarcinoma in patients with primary sclerosing cholangitis

The Number of Positive Tumor Markers (NPTM) Achieves Higher Value in the Prognosis Prediction of Gastric Cancer

Mirrizi Syndrome and Markedly Elevated Levels of Carbohydrate Antigen 19-9 in the Absence of Malignant Disease

Contact Info

Product

Resources

About