Marked Underreporting of Pertussis Requiring Hospitalization in Infants as Estimated by Capture–Recapture Methodology, Germany, 2013–2015

Schielke, Anika; Takla, Anja; Kries, Rüdiger von; Wichmann, Ole; Hellenbrand, Wiebke

doi:10.1097/inf.0000000000001698

Cited by 16 publications

(11 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4 Institut für klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany. 5 Medical Immunology Campus Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany. 6 University of Basel Children's Hospital, Infectious Diseases and Vaccinology, Basel, Switzerland.…”

Section: Discussionunclassified

“…In Germany, mean annual incidence of pertussis among infants aged ≤3 months was 80 per 100,000 during the past 5 years, while hospitalization rate in those young infants was > 75% [RKI, surveillance data, unpublished]. A recent German capturerecapture study suggests that incidences based on statutory surveillance are substantially underestimated by 39% [5]. Since the introduction of nationwide mandatory pertussis reporting in Germany in 2013, two pertussis-related deaths were notified in infants 2 and 4 months of age [6] [RKI, surveillance data, unpublished].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Safety and effectiveness of acellular pertussis vaccination during pregnancy: a systematic review

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Infants < 3 months of age are at highest risk for developing severe complications after pertussis. The majority of pregnant women has low concentrations of pertussis-specific antibodies and thus newborns are insufficiently protected by maternally transferred antibodies. Acellular pertussis vaccination during pregnancy was recently implemented in various countries. Here, we assessed the evidence for safety and effectiveness of pertussis vaccination during pregnancy. Methods: We searched Medline, Embase, and ClinicalTrials.gov from January 1st 2010 to January 10th 2019. We assessed risk of bias (ROB) using the Cochrane ROB tool and ROBINS-I. We evaluated the quality of evidence using the GRADE approach. Results: We identified 1273 articles and included 22 studies (14 for safety; 8 for effectiveness), comprising 1.4 million pregnant women in safety studies and 855,546 mother-infant-pairs in effectiveness studies. No significant differences between vaccinated and unvaccinated women and their infants were observed for safety outcomes with the exception of fever and chorioamnionitis. Compared to no vaccination, three studies showed a significantly increased relative risk for the presence of the ICD-9 code for chorioamnionitis in electronic patient data after pertussis vaccination. However, no study reported an increased risk for clinical sequelae of chorioamnionitis after vaccination during pregnancy, such as preterm birth or neonatal intensive care unit admission. Vaccine effectiveness against pertussis in infants of immunized mothers ranged from 69 to 91% for pertussis prevention, from 91 to 94% for prevention of hospitalization and was 95% for prevention of death due to pertussis. Risk of bias was serious to critical for safety outcomes and moderate to serious for effectiveness outcomes. GRADE evidence quality was moderate to very low, depending on outcome. Conclusion: Although an increased risk for a diagnosis of fever and chorioamnionitis was detected in pregnant women after pertussis vaccination, there was no association with a higher frequency of clinically relevant sequelae. Vaccine effectiveness for prevention of infant pertussis, hospitalization and death is high. Pertussis vaccination during pregnancy has an overall positive benefit-risk ratio. In view of the overall quality of available evidence ongoing surveillance of chorioamnionitis and its potential sequelae is recommended when pertussis vaccination in pregnancy is implemented.

show abstract

Section: Discussionunclassified

Section: Introductionmentioning

confidence: 99%

Safety and effectiveness of acellular pertussis vaccination during pregnancy: a systematic review

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Population-based rates were reported in 10 studies from France, Germany, Israel, Norway, Spain, Sweden, the Netherlands, and the UK, including two reports from France and Spain in the gray literature (Figures 2 and 3) [70][71][72][73][74][75][76][77][78][79][80][81]. The pertussis incidence rate in the <3 month age-group ranged from 155.2 per 100,000 population (Netherlands 2005(Netherlands -2007 to 1114.3 per 100,000 population in Spain during a pertussis epidemic [75,76].…”

Section: Region Of Europementioning

confidence: 99%

A systematic review of the burden of pertussis disease in infants and the effectiveness of maternal immunization against pertussis

Kandeil

Ende²,

Bunge³

et al. 2020

Expert Review of Vaccines

View full text Add to dashboard Cite

Introduction: Infants too young to be fully immunized are the most vulnerable to severe pertussis disease. To close this susceptibility gap, passive infant immunization through vaccination of pregnant women against pertussis was first introduced in 2011 in the United States and has been extended since then to more than 40 countries. Areas covered: We conducted two systematic literature searches to describe the worldwide burden of pertussis disease in infants <6 months of age since 2005, and the effectiveness and impact of maternal pertussis vaccination in preventing infant pertussis since 2011. Expert opinion: Pertussis disease incidence rates in infants aged <2-3 months were substantial in all countries with available data, exceeding 1000 cases per 100,000 population during outbreaks. Virtually all pertussis deaths occurred in this age group. Data from Africa, Eastern Mediterranean, and Asia were limited, but suggest a similar or higher disease burden than in Europe or the Americas. Estimates of effectiveness of second/third trimester pertussis vaccination in preventing pertussis disease in <2-3 months old infants were consistently high (69%-93%) across the observational studies reviewed, conducted in various settings with different designs. Maternal vaccination programs appear to be achieving their goal of reducing the burden of disease in very young infants.

show abstract

“…No reliable data are currently available to estimate the extent of pertussis underreporting by these population-based passive surveillance systems. Underreporting is caused by various factors such as lack of physician awareness, rare treatment seeking behavior among mild pertussis cases, lack of biological diagnosis testing capacity, and absence of user-friendly reporting infrastructure (Crowcroft et al, 2018;Schielke et al, 2018). Thus, we recommend the following alternative options.…”

Section: Surveillance and Epidemiologic Research Recommendationsmentioning

confidence: 99%

Pertussis in the Association of Southeast Asian Nations: epidemiology and challenges

Thisyakorn

Tantawichien

Thisyakorn

et al. 2019

International Journal of Infectious Diseases

View full text Add to dashboard Cite

Pertussis is a highly infectious respiratory disease caused by Bordetella pertussis. Infants and young children are particularly at risk of severe and life-threatening disease. Infectious older individuals may transmit Bordetella pertussis to unprotected infants. Pertussis control measures have even failed in some countries with high pertussis vaccination coverage rates, leading to increased incidence rates. In 2014, this caused the World Health Organization to declare pertussis resurgent in some countries and led to recommendations regarding pertussis surveillance and national immunization programs. Despite the resurgence of pertussis, epidemiology of the disease in Southeast Asia has received little attention. In this narrative review, we describe pertussis surveillance systems, control measures, epidemiologic trends, and region-specific pertussis research in Southeast Asia. We also make recommendations for the intensification of pertussis surveillance and research in the region.

show abstract

Marked Underreporting of Pertussis Requiring Hospitalization in Infants as Estimated by Capture–Recapture Methodology, Germany, 2013–2015

Abstract: Our study revealed a high burden of pertussis in infants with marked under-reporting, especially in western federal states where notification was only recently established. Strategies for the prevention of severe pertussis.

Cited by 16 publications

References 46 publications

Safety and effectiveness of acellular pertussis vaccination during pregnancy: a systematic review

Safety and effectiveness of acellular pertussis vaccination during pregnancy: a systematic review

A systematic review of the burden of pertussis disease in infants and the effectiveness of maternal immunization against pertussis

Pertussis in the Association of Southeast Asian Nations: epidemiology and challenges

Contact Info

Product

Resources

About