Markedly Elevated Cardiac Bio-Markers at Presentation With Normal Ventricular Function: A Novel Clinical Subset of Myocarditis Manifestation

Abstract

We present a case of a 19-year-old woman with myocarditis who had significantly elevated cardiac markers at presentation even before any myocardial damage ensued. The patient had complicated clinical course with ventricular arrhythmia and cardiac arrest requiring resuscitation but eventually recovered completely. Though there is limited information available regarding such cases, the significantly elevated initial cardiac markers in the absence of left ventricular decompensation may probably represent a clinical subset of myocarditis and may portend an impending complicated clinical course. Further systematic research is required to define the clinical phenotype and elucidate underlying mechanisms.

Label-free detection of cardiac troponin I with a photonic crystal biosensor

“…For more than a decade, cardiac troponin I (cTnI) is one of the most widely used biomarkers, due to its nearly complete cardiac tissue specificity and its long serum half-life (Babuin and Jaffe 2005, Reichlin et al 2009, Scharnhorst et al 2011). Clinical data indicated that subjects with even minor elevations of cTnI are at increased risk of premature MI (Palla et al 2011). When a patient with chest pain is seen in the emergency room, blood is routinely drawn to detect any rise in cardiac biomarker concentrations due to heart muscle damages.…”