Marker haplotype association with growth in German cystic fibrosis patients

Tümmler, Burkhard; Aschendorff, Antje; Darnedde, T.; Fryburg, K.; Maaß, G.; Hundrieser, J.

doi:10.1007/bf00200573

Cited by 7 publications

(1 citation statement)

References 22 publications

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“…Placental factors [5] or insulin deficiency [6] have been discussed as possible causes. The association of marker haplotype with height and weight retardation in older patients with CF [26] point to a genetic impact on growth.…”

Section: Discussionmentioning

confidence: 95%

Perspectives of longitudinal growth in cystic fibrosis from birth to adult age

et al. 1994

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The longitudinal growth in 139 patients with cystic fibrosis (CF) was investigated from birth until the age of 19 years. Already at birth weight and length were reduced (weight: -0.83 +/- 0.13 SDS in girls, -0.44 +/- 0.13 SDS in boys; length: 0.55 +/- 0.13 SDS in girls, -0.39 +/- 0.14 SDS in boys; mean +/- SEM). Both variables showed a further decline until diagnosis was established (weight: -1.57 +/- 0.21 SDS in girls, -1.46 +/- 0.25 SDS in boys; length: -1.15 +/- 0.32 SDS in girls, -1.03 +/- 0.52 SDS in boys; mean +/- SEM). Six to 12 months after diagnosis length improved and reached the 25th percentile in both sexes. Height and weight followed the 25th percentile throughout childhood. Growth velocity was fairly normal during this period. There was a loss in percentiles of both height and weight after the age of 8 years and the pubertal growth spurt was delayed and reduced. However, the 25th percentile was reached again in the adolescent period. At the age of 19 years median height was 161.5 cm in girls and 173 cm in boys, both representing the 25th percentile. Using a sensitive statistical method for analysis of growth data we present CF specific growth curves for height, weight and growth velocity. There was no significant effect of pulmonary colonization with Pseudomonas aeruginosa on growth velocity.

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Section: Discussionmentioning

confidence: 95%

Perspectives of longitudinal growth in cystic fibrosis from birth to adult age

et al. 1994

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Differentially delayed development in the hand–wrist skeletons of children with cystic fibrosis: Round versus tubular bones

Mahaney

1991

American J Hum Biol

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From a sample of 50 cystic fibrosis patients in whom a previous study had demosntrated a lack of statistical interdependence between disease severity and significant TW2-20 bone age delays, hand-wrist radiographs for a preadolescent subsample of 30 (14 females and 16 males, 7.4 to 13.0 years of age) are reassessed using the TW2 method to (1) elucidate any significant differences in maturational delays exhibited by the carpals and the tubular bones (radius, ulna, and short bones [RUS]) of the hand-wrist complex and (2) assess the relationships between the clinically derived measure of pulmonary disease severity, anthropometric indices of nutritional status, and the bone age delays in these two regions. Female and male carpal bone age delays, pulmonary disease severity scores, and weight/height differ significantly. However, both sexes exhibit significant mean TW2-carpal bone age delays, while mean TW2-RUS ages are either non-significantly delayed or advanced with respect to normative standards. Correlation and all-subsets multiple linear regression analyses reveal no significant interdependence or predictive relationships between clinically derived measures of pulmonary disease severity and anthropometric measures of nutritional complications and delayed skeletal maturation in either the carpals or tubular bones of the hand-wrist complex.

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