Markers of Atrial Myopathy: Widening the Echocardiographic Window for Early Detection of Myocardial Disease

Yaramada, Priyanka; Pai, Ramdas G.

doi:10.1111/echo.13136

Cited by 1 publication

(3 citation statements)

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“…The LA volume index is more precise and therefore more suitable for estimating atrial size (Figure 3B). Increased LA volume index has been described as a potential early marker of myocardial dysfunction and is often present in patients with AF, with increasing frequency in a higher AF burden (51,52). Besides, the minimal LA volume strongly correlates with the incidence of new-onset AF and major adverse cardiovascular events compared to the maximal LA volume that seems to have no predictive effects (53)(54)(55)(56).…”

Section: Left Atrial Sizementioning

confidence: 99%

“…In the past, numerous echocardiographic parameters relating transmitral blood flow and diastolic myocardial motion have been investigated for association with LA function and clinical events ( 51 , 52 , 58 , 59 ). However, no parameter and corresponding cut-off value have yet been identified as suitable for the diagnosis of LACM.…”

Section: Echocardiographymentioning

confidence: 99%

“…A reduced mitral annular “e”-wave velocity and an increased E/e ratio provide signs of impaired LV relaxation. There is evidence that the latter parameter is also suitable to assess LA function and pressure ( 52 ) ( Figures 3C,D ).…”

Section: Echocardiographymentioning

confidence: 99%

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Left Atrial Cardiomyopathy – A Challenging Diagnosis

Kreimer

Gotzmann

2022

Front. Cardiovasc. Med.

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Left atrial cardiomyopathy (LACM) has been an ongoing focus of research for several years. There is evidence that LACM is responsible for atrial fibrillation and embolic strokes of undetermined sources. Therefore, the correct diagnosis of LACM is of clinical importance. Various techniques, including electrocardiography, echocardiography, cardiac magnetic resonance imaging, computed tomography, electroanatomic mapping, genetic testing, and biomarkers, can both identify and quantify structural, mechanical as well as electrical dysfunction in the atria. However, the question arises whether these techniques can reliably diagnose LACM. Because of its heterogeneity, clinical diagnosis is challenging. To date, there are no recommendations for standardized diagnosis of suspected LACM. However, standardization could help to classify LACM more precisely and derive therapeutic directions to improve individual patient management. In addition, uniform diagnostic criteria for LACM could be important for future studies. Combining several parameters and relating them seems beneficial to approach the diagnosis of LACM. This review provides an overview of the current evidence regarding the diagnosis of LACM, in which several potential parameters are discussed and, consequently, a proposal for a diagnostic algorithm is presented.

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