Markers of Bone Mineral Metabolism and Cardiac Structure and Function in Perinatally HIV-Infected and HIV-Exposed but Uninfected Children and Adolescents

Margossian, Renée; Williams, Paige L.; Yu, Wendy; Jacobson, Denise L.; Geffner, Mitchell E.; DiMeglio, Linda A.; Dyke, Russell B. Van; Spector, Stephen A.; Schuster, Gertrud U.; Stephensen, Charles B.; Miller, Tracie L.; Lipshultz, Steven E.

doi:10.1097/qai.0000000000002007

Cited by 4 publications

(7 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lipshultz et al described how low PTH level and subsequently lower intracellular calcium concentrations in patients with chronic renal disease correlated strongly with ischemia, depressed contractibility, and adverse outcomes [34] . Similarly, Margosian et al described that vitamin D deficiency and elevated PTH levels were associated with lower LV mass z-scores while FGF-23 was inversely related to end-diastolic septal thickness [35] . Similarly, we described that patients with MIS-C and severe vitamin D deficiency had reduced left ventricular ejection and shortening fraction compared to their counterparts with MIS-C and normal vitamin D levels, although, our cohort was small.…”

Section: Discussionmentioning

confidence: 91%

Vitamin D and morbidity in children with Multisystem inflammatory syndrome related to Covid-19

Torpoco-Rivera¹,

Misra²,

Sanil³

et al. 2022

Progress in Pediatric Cardiology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 91%

Vitamin D and morbidity in children with Multisystem inflammatory syndrome related to Covid-19

Torpoco-Rivera¹,

Misra²,

Sanil³

et al. 2022

Progress in Pediatric Cardiology

View full text Add to dashboard Cite

“…VDRs are expressed in many cells and tissues of the cardiovascular system, including vascular smooth muscles, endothelia, and myocardia [ 54 , 55 ]. Margossian et al found that vitamin D deficiency is associated with lower LV mass z-scores [ 56 ]. McNally et al demonstrated that VD deficiency was associated with prolonged mechanical ventilation and ICU stays after pediatric cardiac surgery [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Vitamin D Levels on Clinical Manifestations of Multisystem Inflammatory Syndrome in Children: A Cross-Sectional Study

Petrović

Benzon

Sršen

et al. 2023

Life

View full text Add to dashboard Cite

Background: Hyperinflammatory response that resembles Kawasaki disease may develop in children after COVID-19 disease, and it is called multisystem inflammatory syndrome in children. The cause of MIS-C is dysregulated innate immune response and a subsequent cytokine storm that results in endothelial damage. It has been determined that low levels of serum 25(OH)D increase the risk of developing immune-related diseases and disorders. Methods: To determine the incidence of hypovitaminosis D, and a possible correlation between 25(OH)D levels and the clinical severity of MIS-C, 21 patients hospitalized in the University Hospital of Split due to MIS-C were evaluated. Results: Hypovitaminosis D was detected in 95% of MIS-C patients. We found a significant relationship between the severity of MIS-C and 25(OH)D levels, as patients with more severe MIS-C had lower 25(OH)D. MIS-C patients with lower vitamin D levels had worse systolic and diastolic function of the left ventricle according to echocardiograms. There was no relationship between 25(OH)D levels and the tested laboratory inflammatory and cardiac markers. Conclusion: Hypovitaminosis D is very common in children with MIS-C and influences the severity of the disease. VD could be a new potential biomarker in MIS-C, and VD replacement therapy should be considered early on in the treatment of MIS-C.

show abstract

“…Fibroblast growth factor 23 (FGF-23) was reported at 24-month visit. Those with 25(OH)D3 less than 20 ng/ ml were considered having vitamin D insufficiency status [31].…”

Section: Bone Turnover Markersmentioning

confidence: 99%

Persistently lower bone mass and bone turnover among South African children living with well controlled HIV

Shen

Shiau

Strehlau

et al. 2021

Aids

View full text Add to dashboard Cite

Objective: We evaluated longitudinal trends and associations between bone mass, bone turnover and inflammatory markers among South African children living with HIV (CLHIV) and controls.Design: We previously reported decreased bone mass among CLHIV independent of marked inflammation and increased bone turnover. The goal of this study was to evaluate longitudinal changes in bone mass, bone turnover and inflammation over 2 years.Methods: Longitudinal analyses were conducted among 220 CLHIV and 220 controls. Anthropometric measurements, physical activity, antiretroviral regimen, virologic and immunologic status, whole body (WB) and lumbar spine (LS) bone mineral content (BMC) and bone mineral density (BMD) were collected (enrollment, 12 and 24 months). Bone turnover markers including C-telopeptide of type I collagen (CTx) and procollagen type I N-terminal propeptide (P1NP) and inflammatory markers including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), soluble CD14 and high-sensitivity Creactive protein (hsCRP) were collected at enrollment and 24 months.Results: Compared with controls, CLHIV had significantly lower mean WB-BMC, WB-BMD, WB-BMC z scores, LS-BMC and LS-BMD as well as lower bone formation (P1NP) and resorption (CTx), and higher hsCRP and soluble CD14 over 24 months. CLHIV on efavirenz (EFV) had consistently lower TNF-alpha and IL-6 compared with those on ritonavir-boosted lopinavir (LPV/r) at all time points. Conclusion:Over 2 years of follow-up, South African CLHIV had persistently lower bone mass, bone turnover, and macrophage activation. Lower bone mass and higher pro-inflammatory cytokine profiles were consistently observed among those on LPV/ r-based compared with EFV-based regimens.

show abstract

Markers of Bone Mineral Metabolism and Cardiac Structure and Function in Perinatally HIV-Infected and HIV-Exposed but Uninfected Children and Adolescents

Abstract: Background: Disordered bone mineral metabolism and low vitamin D concentrations are associated with cardiovascular abnormalities; few studies have evaluated this relationship in HIVinfected youth.

Cited by 4 publications

References 33 publications

Vitamin D and morbidity in children with Multisystem inflammatory syndrome related to Covid-19

Vitamin D and morbidity in children with Multisystem inflammatory syndrome related to Covid-19

The Impact of Vitamin D Levels on Clinical Manifestations of Multisystem Inflammatory Syndrome in Children: A Cross-Sectional Study

Persistently lower bone mass and bone turnover among South African children living with well controlled HIV

Contact Info

Product

Resources

About