Markers of connective tissue activation in aseptic hip prosthetic loosening

Moreschini, O.; Fiorito, Silvana; Magrini, L.; Margheritini, Fabrizio; Romanini, L

doi:10.1016/s0883-5403(97)90144-3

Cited by 23 publications

(15 citation statements)

References 26 publications

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“…Advances in our understanding of this response, largely derived from various retrieval studies [1][2][3] has lead to investigations at a cellular level, leading to the conclusion that macrophages can be significant in determining the duration and intensity of the inflammatory response [4][5][6][7] and therefore as a driving mechanism behind the failure of a primary joint replacement caused by aseptic loosening. Due to this, several studies have investigated macrophage behaviour in response to exposure to various substrates and associated wear particles, both in vitro and in vivo, quantitatively and qualitatively [6][7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

The inflammatory potential of biphasic calcium phosphate granules in osteoblast/macrophage co-culture

2005

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Section: Introductionmentioning

confidence: 99%

The inflammatory potential of biphasic calcium phosphate granules in osteoblast/macrophage co-culture

2005

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“…Moreschini et al . [13] found no significant difference in type III procollagen peptide levels in patients with loosened hip prostheses when compared to controls with osteoarthritis.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies [13-15] evaluated serum IL-1 β as a biomarker for arthroplasty loosening. Hundri-Haspl et al .…”

Section: Resultsmentioning

confidence: 99%

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Biomarkers in Arthroplasty: A Systematic Review

Mertens

Singh²

2011

TOORTHJ

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We performed a systematic review of all MEDLINE-published studies of biomarkers in arthroplasty. Thirty studies met the inclusion criteria; majority evaluated biomarkers for osteolysis, aseptic prosthetic loosening, and prosthetic infections. Four studies reported an elevated Cross-linked N-telopeptides of type I collagen (urine or serum) in patients with osteolysis or aseptic prosthetic loosening when compared to appropriate controls. Two or more studies each found elevated C-reactive protein, erythrocyte sedimentation rate, and interleukin-6 in patients with infected prosthetic joints compared to controls. Most other biomarkers were either examined by single studies or had inconsistent or insignificant associations with outcomes. We conclude that the majority of the biomarkers currently lack the evidence to be considered as biomarkers for arthroplasty outcomes. Further studies are needed.

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“…[45][46][47] Most such studies have dealt with cytokines, metalloproteinases, and collagens which the fibroblasts from interfacial membrane produced, or with the growth of the interfacial membrane. As far as we know this study is the first report which shows that the granulation fibroblasts from the granulation tissue inside the pseudocapsule can support osteoclast differentiation.…”

Section: Discussionmentioning

confidence: 99%

Fibroblasts from the inner granulation tissue of the pseudocapsule in hips at revision arthroplasty induce osteoclast differentiation, as do stromal cells

Sakai

2002

Annals of the Rheumatic Diseases

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Background: It has previously been shown that many osteoclast precursors are included in the granulation tissue within the pseudocapsule obtained at revision arthroplasty from hips with osteolysis. In vitro culture of only cells isolated from the granulation tissue has been previously shown to generate many mature osteoclasts. Objective: To investigate the presence or otherwise of supporting cells, similar to stromal cells, which differentiate osteoclasts within the granulation tissue. Methods: Cells isolated from the granulation tissue were cultured alone, and after four weeks fibroblast-like cells (granulation fibroblasts) remained. Rat non-adherent bone marrow cells (NA-BMCs) were co-cultured with the granulation fibroblasts with or without 1α,25(OH) 2 D 3 (10 −8 M) or heat treated ROS 17/2.8 cell conditioned medium (ht ROSCM), or both. Multinucleated cells (MNCs), which formed, were assessed by biochemical and functional characterisation of osteoclasts. Receptor activator of NFκB ligand (RANKL) was investigated by immunohistochemistry. Results: Co-culture of NA-BMCs and granulation fibroblasts caused the formation of tartrate resistant acid phosphatase (TRAP) positive MNCs, which had the calcitonin receptor (CTR), the Kat-1 antigen, which is specific to the surface of rat osteoclasts, and the ability to form pits in the presence of both 1α,25(OH) 2 D 3 and ht ROSCM or in the presence of just ht ROSCM. RANKL was detected in fibroblastlike cells in the granulation tissue. Conclusion: These data suggest that granulation fibroblasts support osteoclast differentiation, as do osteoblasts/stromal cells, and may play a part in aseptic loosening.

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Markers of connective tissue activation in aseptic hip prosthetic loosening

Cited by 23 publications

References 26 publications

The inflammatory potential of biphasic calcium phosphate granules in osteoblast/macrophage co-culture

The inflammatory potential of biphasic calcium phosphate granules in osteoblast/macrophage co-culture

Biomarkers in Arthroplasty: A Systematic Review

Fibroblasts from the inner granulation tissue of the pseudocapsule in hips at revision arthroplasty induce osteoclast differentiation, as do stromal cells

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