Markers of Cow’s Milk Allergy Persistence: Results of a 5-Year Follow-Up

In recent years, more and more attention has been paid to the problem of control and (PDF) maintenance of nutritional status in patients with elimination diet for food allergies. The high effectiveness of this treatment method is associated with the risk of nutritional deficiency, impaired physical growth and eating behavior disorders in children due to the possible long-term elimination of important food groups without adequate replacement. This review considers physical growth disorders in children with food allergies due to insufficient intake of micronutrients (vitamins, fatty acids), as well as such behavior disorders as distortion of food and taste preferences and food neophobia. We also discuss the problems of artificial mixture choice in children of the first year of life, correction of the diet in children over one year of age with micronutrient supplementation, as well as the results of studies on the quality of life of both children with elimination diets and people from their families. When prescribing an elimination diet, the doctor must constantly monitor diet and growth indices of the child. It is necessary to take to into account the child's age, his nutritional requirements and possible deficiencies of nutrients while planning the diet, as well as determine the necessary and sufficient diet duration.

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The problems of long-term adherence to elimination diets in children with food allergies

Емельяшенков

Макарова

Fisenko

et al. 2022

Russian Journal of Allergy

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Clinical phenotypes of cow’s milk food allergy in children depending on the molecular profile of sensitization

Приходченко

Шуматова

Katenkova

et al. 2022

Allergol. immunol. pediatr.

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Introduction. Sensitization to cow’s milk (CM) is one of the most common causes of food allergy (FA) in young children; its clinical manifestations in children are varied, since many organs and systems can be involved in the pathological process. The purpose: to study the profile of IgE sensitization to the molecular components of CM in children, depending on the clinical phenotype of the disease. Materials and Methods. Clinical and laboratory examination of 148 children from birth to 12 months with IgE-mediated FA to CM was carried out. The study of sIgE to cow’s milk, nBos d 8, nBos d 4, nBos d 5, nBos d 6 was carried out by the Immuno CAP method. Statistical processing was performed using the Statistica for Windows v. 10.0, StatSoft Inc. (USA). Results: The conducted clinical and laboratory analysis allowed us to identify the skin (33.3%; 49/148), gastrointestinal (23.5%; 35/148) and mixed (43.2%; 64/148) phenotype of CMA in children. In the structure of clinical phenotypes, the frequency of the mixed phenotype prevailed over the skin (χ2 = 20.51, p < 0.00001) and gastrointestinal phenotype (χ2 = 27.84, p < 0.00001). Sensitization to nBos d 4 has the greatest influence on the formation of the gastrointestinal phenotype (χ2 = 18.67, p = 0.0001). In the formation of skin manifestations, combined sensitization to nBos d 8 + nBos d 6 (χ2 = 14.96, p = 0.0003), nBos d 8 + nBos d 5 (χ2 = 28.44, p < 0.00001) was more common. Conclusion. The results of the study showed the importance of cow’s milk components in the formation of the clinical phenotype of the disease and can be used to personalize the diagnosis and therapeutic strategy.

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Markers of Cow’s Milk Allergy Persistence: Results of a 5-Year Follow-Up

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The problems of long-term adherence to elimination diets in children with food allergies

The problems of long-term adherence to elimination diets in children with food allergies

Clinical phenotypes of cow’s milk food allergy in children depending on the molecular profile of sensitization

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