Markers of disease severity in chronic obstructive pulmonary disease

Franciosi, Luigi G.; Page, Clive; Celli, Bartolomé R.; Cazzola, Mario; Walker, Michael J.; Danhof, Meindert; Rabe, Klaus F.; Pasqua, Oscar Della

doi:10.1016/j.pupt.2005.05.001

Cited by 129 publications

(89 citation statements)

References 53 publications

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“…The best known among these markers is CRP. Elevated systemic CRP levels have been found associated with the increase in disease severity, deterioration in health condition, hospitalization, and mortality rates in COPD [8,28,29]. In our study, CRP and ESR levels were found higher in both COPD groups when compared with the controls.…”

Section: Discussionsupporting

confidence: 56%

The Importance of Neutrophil-to-Lymphocyte Ratio in Chronic Obstructive Pulmonary Disease

İn

Kuluöztürk

Öner

et al. 2016

Turk Toraks Dergisi

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OBJECTIVES: Chronic obstructive pulmonary disease (COPD) is a common lung disease characterized by airflow limitation and systemic inflammation. Recently, neutrophil-to-lymphocyte ratio (NLR) has gathered increasing interest in the detection of inflammation in inflammatory diseases. This study aimed to investigate the role of NLR in COPD for identifying the detection of inflammation and recognition of acute exacerbation. MATERIAL AND METHODS:The laboratory results of 103 COPD patients were included into the study, of which 47 patients were in acute exacerbation and 56 patients were at stable period, and there were 40 gender and age-matched healthy controls. Complete blood count (CBC), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were evaluated. NLR was calculated from CBC. RESULTS:NLR values of patients with COPD (both acutely exacerbated and stable) were found significantly higher than those of the controls (p< 0.001, p< 0.05; respectively). In all patients with COPD, NLR values positively correlated with serum CRP (r= 0.641, p< 0.001) and ESR (r= 0.276, p= 0.005) levels and negatively correlated with forced vital capacity (r= -0.20, p= 0.043) and forced expiratory volume in the 1 st second (r= -0.288, p= 0.003). For an NLR cutoff of 3.34, sensitivity for detecting exacerbation of COPD was 78.7% and specificity was 73.2% (AUC 0.863, p< 0.001). CONCLUSION:Our results suggest that NLR may be considered as a reliable and simple indicator in the determination of increased inflammation in patients with COPD. Furthermore, NLR could be useful for the early detection of possible acute exacerbations in patients with COPD.

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Section: Discussionsupporting

confidence: 56%

The Importance of Neutrophil-to-Lymphocyte Ratio in Chronic Obstructive Pulmonary Disease

İn

Kuluöztürk

Öner

et al. 2016

Turk Toraks Dergisi

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“…It is well known that granulocytes play an important role in asthma and COPD [14,15] but although neutrophilia has been associated with asthma severity, debate remains whether neutrophilia is a characteristic of asthma severity or results from glucocorticoid treatment [5,8,[16][17][18][19][20][21][22][23][24]. More severely ill asthma patients receive often higher doses of glucocorticoids and glucocorticoids are highly used among hospitalized asthma patients.…”

Section: Introductionmentioning

confidence: 99%

Effects of glucocorticoids on the neutrophil count: A cohort study among hospitalized patients

Velthove

Leufkens

Souverein

et al. 2010

Pulmonary Pharmacology & Therapeutics

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Please cite this article as: Velthove KJ, Leufkens HGM, Souverein PC, Schweizer RC, Bracke M, van Solinge WW. Effects of glucocorticoids on the neutrophil count: a cohort study among hospitalized patients, Pulmonary Pharmacology & Therapeutics (2009), doi: 10.1016/j.pupt.2009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. with glucocorticoid use or that other factors, like disease and severity of disease, should be considered. The objective of this study was to investigate the effect of systemic glucocorticoids on the absolute neutrophil count in hospitalized patients. M A N U S C R I P T A C C E P T E D ARTICLE IN PRESSMethods: A cohort study was conducted using data from the Utrecht Patient OrientedDatabase which comprises clinical data of patients of the University Medical Center Utrecht.We identified all adult patients, hospitalized in 2005 with at least two blood samples for hematological testing during admission and compared in hospital glucocorticoid use with nonuse.Results: A total of 809 glucocorticoid users and 2,658 non-users were included in the study with comparable neutrophil counts at admission (8.2.10 9 /l for glucocorticoid users and 8.0.10 9 /l for non-users). Overall analysis showed a slight association between glucocorticoid use and an increase in neutrophil count (RR 1.3; 95% CI 1.1-1.5). However, within diagnostic subgroups there was no increase in neutrophil count in glucocorticoid users. Furthermore, among all no dose response relationship, no effect of time between the two samples, and no effect of anti-inflammatory/sodium retaining potency was found. Conclusion:Observed neutrophilia in users of systemic glucocorticoids is probably associated with underlying disease, rather than glucocorticoid use itself.

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“…Obstruktionsparameter, Reversibilität, CO−Diffusion, 6−min−Gehtest, Compliance Die FEV 1 ist der am besten evaluierte Parameter zur Quantifizierung einer Atemwegsobstruktion [4]. Nach internationalen und nationalen Leit− linien stützt sich der Nachweis einer COPD auf den Schwellenwert der FEV 1 …”

Section: Lungenfunktionunclassified