Markers of hepatitis viruses and human T-lymphotropic virus types I/II in patients who have undergone open-heart surgery: Evidence of increased risk for exposure to HBV and HEV

Zervou, Eleftheria; Georgiadou, Sarah P.; Liapi, G.; Karabini, F.; Giogiakas, Vassilios; Zisiadis, K.; Gatselis, Nikolaos; Goudevenos, Ioannis; Dalekos, Georgios N.

doi:10.1016/j.ejim.2005.02.020

Cited by 4 publications

(5 citation statements)

References 26 publications

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“… N Prevalence (%) Ref. Prevalence (%)* France 1 b 5.9 [23] 1 0.7 [27] 0.7–0.8 Greece 1 5.5 [32] 1 c 2 [22] 2.9–3.3 Italy 1 1.9 [43] 1 d 4 [21] 1 1.6 [25] 0.7–0.8 Lithuania 1 11.7 [17] 0.6 Poland 1 9.8 [24] 3 e 0.6–1.2 [28] , [29] , [30] 0.5 Romania 2 7.9–9.5 [18] , [19] 1 2.2 [18] 4.4 Spain 1 a …”

Section: Resultsmentioning

confidence: 99%

“… N Prevalence (%) Ref. Prevalence* (%) France 3 7.7–16.3 [31] , [44] , [45] 1 a 1.4–3.2 [27] 2 d 8.2–47.1 [23] , [27] 3 g 2.1–8.2 [27] 0.8 Germany 2 3.6–5.2 [46] , [47] 1 b 11.3 [48] 0.4 Greece 2 24–29 [32] , [33] 2 e 2–54.2 [22] , [49] 2.2 Italy 2 15.1–18.8 [34] , [35] 1 c 8.9 [50] 4 f 35.5–95.4 [21] , [51] 1 5.9 <...>…”

Section: Resultsmentioning

confidence: 99%

“…One study from Spain [20] reports relatively high prevalence of HBV (7.8%) among a sample of haemodialysis patients living with HIV. All four studies reporting on SOHO recipients were performed in the early 2000s, some sampled patients hospitalized before 1991 [21] , [22] and some sampled HIV- or HCV-infected individuals [23] , [24] . Of the three studies on diabetes patients, two were conducted in the second half of the 2000s among outpatients [25] , [26] , and the third was an older study conducted among hospitalized patients only [27] .…”

Section: Resultsmentioning

confidence: 99%

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Hepatitis B and C among healthcare workers and patient groups at increased risk of iatrogenic transmission in the European Union/European Economic Area

Tavoschi

Mason²,

Petriti³

et al. 2019

Journal of Hospital Infection

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Summary In the European Union/European Economic Area (EU/EEA) approximately 9 million people are chronically infected with hepatitis B virus (HBV) or hepatitis C virus (HCV), and many are undiagnosed. Targeted active case finding initiatives are needed. Iatrogenic transmission of HBV/HCV is relevant in Europe but people at risk of infection are often overlooked. This study aimed to identify groups at increased risk of HBV/HCV infection due to iatrogenic transmission, including healthcare workers, and to estimate incidence and prevalence. PubMed and Embase were systematically searched in February 2017 using strings combining terms for HBV/HCV, occurrence and population subgroups. All retrieved publications were screened and included articles were quality assessed. A predefined set of variables were extracted, and detailed summary tables were developed per population group of interest, virus and outcome. Thirty-eight articles were included, two reported on HBV, 22 on HCV and 16 on both, contributing 70 estimates of prevalence or incidence among: haemodialysis recipients, diabetes patients, recipients of substances of human origin, recipients of medical/dental procedures and healthcare workers. Estimates varied widely from 0.4% to 11.7% for HBV and from 0.7% to over 90% for HCV with most being higher than in the general population. Despite the limited number of studies retrieved, mostly old and focused on populations with multiple risk factors, our findings highlight the importance of considering population groups at higher risk for HBV/HCV iatrogenic transmission as target groups for active case finding in the EU/EEA. Test offers should be guided by individual risk assessment alongside local epidemiological data and local context.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Hepatitis B and C among healthcare workers and patient groups at increased risk of iatrogenic transmission in the European Union/European Economic Area

Tavoschi

Mason²,

Petriti³

et al. 2019

Journal of Hospital Infection

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“…Another study from the Epirius region (Ioannina) analyzed the risk of blood borne HEV transmission among patients after open-heart surgery who had received more than three blood units perioperatively. Past HEV infections were documented in 5.2% of surgical patients and 0% of healthy controls[43].…”

Section: Greecementioning

confidence: 99%

Epidemiology of hepatitis E in South-East Europe in the "One Health" concept

Mrzljak¹,

Dinjar-Kujundzic²,

Jemeršić³

et al. 2019

WJG

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The significance of hepatitis E virus (HEV) as an important public health problem is rising. Until a decade ago, cases of HEV infection in Eur-ope were mainly confined to returning travelers, but nowadays, hepatitis E represents an emerging zoonotic infection in many European countries. The aim of this manuscript is to perform a systematic review of the published literature on hepatitis E distribution in humans, animals and environmental samples ("One Health" concept) in the South-Eastern European countries. Comparison of the available data showed that the anti-HEV seroprevalence in the South-Eastern Europe varies greatly, depending on the population studied, geographical area and methods used. The IgG seroprevalence rates in different population groups were found to be 1.1%-24.5% in Croatia, up to 20.9% in Bulgaria, 5.9-%17.1% in Romania, 15% in Serbia, up to 9.7% in Greece and 2%-9.7% in Albania. Among possible risk factors, older age was the most significant predictor for HEV seropositivity in most studies. Higher seroprevalence rates were found in animals. HEV IgG antibodies in domestic pigs were detected in 20%-54.5%, 29.2%-50%, 38.94%-50% and 31.1%-91.7% in Serbia, Bulgaria, Romania and Croatia, respectively. In wild boars seroprevalence rates were up to 10.3%, 30.3% and 31.1% in Romania, Slovenia and Croatia, respectively. A high HEV RNA prevalence in wild boars in some countries (Croatia and Romania) indicated that wild boars may have a key role in the HEV epidemiology. There are very few data on HEV prevalence in environmental samples. HEV RNA was detected in 3.3% and 16.7% surface waters in Slovenia and Serbia, respectively. There is no evidence of HEV RNA in sewage systems in this region. The available data on genetic characterization show that human, animal and environmental HEV strains mainly belong to the genotype 3.

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“…Studies from Thesallia among health donors also showed a varying seroprevalence of 1.8-9.8% [33]. In Epirus and the Agrinion region, seropositivity was much lower reaching 5.3% among patients with chronic viral hepatitis, 5.2% among open heart surgical patients, 1.34% in patients on hemodialysis, and barely reaching 0.23% among healthy blood donors [34,35]. A recent study in northern Greece confirmed no past or acute HEV infection in transfusion-dependent thalassemia patients [36], while a recent study in the same area found that only 1.3% of liver transplant patients were positive for HEV RNA [37].…”

Section: Discussionmentioning

confidence: 98%

Testing Hepatitis E Seroprevalence among HIV-Infected Patients in Greece: The SHIP Study

Antonopoulou,

Schinas,

Kotsiri

et al. 2024

Pathogens

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Hepatitis E virus (HEV) poses significant health concerns worldwide, particularly among people living with HIV (PLWHIV), due to an increased risk of chronic infection and progression to cirrhosis in individuals with low CD4 cell counts. This study aimed to investigate the prevalence, chronicity potential, and risk factors of HEV infection among PLWHIV in Greece, where data are currently absent. A synchronic multicentric study encompassing five major Greek university hospitals was executed over 24 months, recruiting 696 PLWHIV participants. The prevalence of HEV IgG antibodies was 16.5%, with 8.6% showing evidence of acute HEV infection (HEV IgM). Active viral replication (HEV RNA) was present in 2.3% of the study population. Longitudinal analysis revealed that of the 25 initially anti-HEV IgM-positive individuals, only 3 seroconverted to IgG positivity, and among those with prior HEV RNA positivity (16), none showed evidence of active replication in subsequent tests. Comparative subgroup analysis highlighted the lack of significant differences in HIV-related parameters between HEV seropositive and seronegative individuals. Laboratory evaluations generally showed no significant disparities across most parameters; however, a higher seropositivity for Hepatitis A was observed in the HEV-positive subgroup. Our findings highlight a considerable prevalence of HEV among PLWHIV in Greece, with no observed cases of chronicity.

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Markers of hepatitis viruses and human T-lymphotropic virus types I/II in patients who have undergone open-heart surgery: Evidence of increased risk for exposure to HBV and HEV

Cited by 4 publications

References 26 publications

Hepatitis B and C among healthcare workers and patient groups at increased risk of iatrogenic transmission in the European Union/European Economic Area

Hepatitis B and C among healthcare workers and patient groups at increased risk of iatrogenic transmission in the European Union/European Economic Area

Epidemiology of hepatitis E in South-East Europe in the "One Health" concept

Testing Hepatitis E Seroprevalence among HIV-Infected Patients in Greece: The SHIP Study

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