Markers of increased risk in primary mitral regurgitation

Mentias, Amgad; Desai, Milind Y.

doi:10.21037/atm.2017.04.08

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…In severe mitral regurgitation, GLS appeared to be a better predictor of cardiac events and mortality, regardless of LV dysfunction ( 25 ). In asymptomatic primary mitral regurgitation, the risk of death progressively increased as GLS worsened to ≥−21% ( 26 ). In moderate to severe aortic stenosis, a GLS ≥-12.1% was associated with poor survival ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

Global longitudinal strain in chronic asymptomatic aortic regurgitation: systematic review

et al. 2020

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Chronic aortic regurgitation (AR) patients typically remain asymptomatic for a long time. Left ventricular mechanics, namely global longitudinal strain (GLS), has been associated with outcomes in AR patients. The authors conducted a systematic review to summarize and appraise GLS impact on mortality, the need for aortic valve replacement (AVR) and disease progression in AR patients. A literature search was performed using these key terms 'aortic regurgitation' and 'longitudinal strain' looking at all randomized and nonrandomized studies conducted on chronic aortic regurgitation. The search yielded six observational studies published from 2011 and 2018 with a total of 1571 patients with moderate to severe chronic AR. Only two studies included all-cause mortality as their endpoint. The other studies looked at the association between GLS with AVR and disease progression. The mean follow-up period was 4.2 years. We noted a great variability of clinical, methodological and/or statistical origin. Thus, meta-analytic portion of our study was limited. Despite a relevant heterogeneity, an impaired GLS was associated with adverse cardiac outcomes. Left ventricular GLS may offer incremental value in risk stratification and decision-making.

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Section: Discussionmentioning

confidence: 99%

Global longitudinal strain in chronic asymptomatic aortic regurgitation: systematic review

et al. 2020

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Global longitudinal strain to predict left ventricular dysfunction in asymptomatic patients with severe mitral valve regurgitation: literature review

et al. 2019

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The optimal treatment strategy for asymptomatic patients with severe mitral valve regurgitation (MR) and preserved left ventricular (LV) function is challenging. This manuscript reviews the available literature on the value of left ventricular global longitudinal strain (LV-GLS) in predicting LV dysfunction after mitral valve surgery in these patients and discusses its current place in the treatment strategy. Studies were identified from Cochrane Library, SCO-PUS, PubMed and Web of Science up to February 2018. The domain used was MR. The determinant was LV-GLS; other methods of deformation imaging were excluded. The examined outcome was LV dysfunction after surgery. A total of 144 articles were retrieved, of which 11 publications met the inclusion criteria, including a total of 2415 patients. Ten studies showed a significant correlation between preoperative LV-GLS and LV dysfunction postoperatively; one study reported a negative correlation. These studies suggest that LV-GLS is a predictor of LV dysfunction after surgery in asymptomatic patients with chronic MR. Hence, incorporation of LV-GLS for clinical decision-making in these patients might be of additional value. Further research is needed to confirm the role of LV-GLS in postoperative patients, and additionally

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Markers of increased risk in primary mitral regurgitation

Cited by 2 publications

References 18 publications

Global longitudinal strain in chronic asymptomatic aortic regurgitation: systematic review

Global longitudinal strain in chronic asymptomatic aortic regurgitation: systematic review

Global longitudinal strain to predict left ventricular dysfunction in asymptomatic patients with severe mitral valve regurgitation: literature review

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