Markers of Inflammation and Coagulation after Long-Term Exposure to Coarse Particulate Matter: A Cross-Sectional Analysis from the Multi-Ethnic Study of Atherosclerosis

Adar, Sara D.; D’Souza, Jennifer; Mendelsohn-Victor, Kari; Jacobs, David R.; Cushman, Mary; Sheppard, Lianne; Thorne, Peter S.; Burke, Gregory L.; Daviglus, Martha L.; Szpiro, Adam A.; Roux, Ana V. Diez; Kaufman, Joel D.; Larson, Timothy V.

doi:10.1289/ehp.1308069

Cited by 31 publications

(27 citation statements)

References 60 publications

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“…Furthermore, we demonstrated that these changes were specific to the PM 2.5 fraction of particles, as coarse particles in this study were not associated with systemic markers of inflammation, adding to recent evidence that also suggests very limited effects of coarse PM upon inflammatory markers [27]. Ambient PM has been shown to mobilize the hemopoietic system into releasing leukocytes, including neutrophils and monocytes, into the peripheral circulation, suggesting an effect of PM on bone marrow [28].…”

Section: Discussionsupporting

confidence: 68%

Indoor Particulate Matter Associated with Systemic Inflammation in COPD

Bose¹,

Hansel²,

Tonorezos³

et al. 2015

JEP

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Chronic obstructive pulmonary disease (COPD) is a chronic disease characterized by progressive airflow obstruction, along with pulmonary and systemic inflammation. Outdoor PM has been associated with morbidity and mortality in COPD but less is known about effects of indoor air quality. In former smokers with COPD, we investigated in-home PM effects on pulmonary and systemic inflammation, symptoms, and lung function. Participants underwent in-home air monitoring for two weeks and simultaneous health assessments. Median (IQR) PM2.5 was 9 (7) µg/m 3 . Increased indoor PM2.5 was associated with increased white blood cells, predominantly neutrophils and lymphocytes, suggesting that even relatively low indoor PM2.5 may elicit a systemic inflammatory response in COPD.

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Section: Discussionsupporting

confidence: 68%

Indoor Particulate Matter Associated with Systemic Inflammation in COPD

Bose¹,

Hansel²,

Tonorezos³

et al. 2015

JEP

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“…21 Rioux et al 17 reported an association between residential exposure to traffic and CRP among older Puerto Rican adults in Boston, while a German study found an association between PM 2.5 exposure and both CRP and fibrinogen in men but not in women 31 and no association with measures of traffic. However, Forbes et al 19 and Adar et al 37 found no association between PM 10 exposure and either CRP or fibrinogen. A study conducted among diabetics in Belgium 20 failed to find an association between PM 10 exposure in the past year and Factor VIIc.…”

Section: Discussionmentioning

confidence: 94%

Long-and Short-Term Exposure To Air Pollution and Inflammatory/Hemostatic Markers in Midlife Women

Green¹,

Broadwin²,

Malig³

et al. 2015

Epidemiology

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Background Studies have reported associations between long-term air pollution exposures and cardiovascular mortality. The biological mechanisms connecting them remain uncertain. Methods We examined associations of fine particles (PM2.5) and ozone with serum markers of cardiovascular disease risk in a cohort of midlife women. We obtained information from women enrolled at six sites in the multi-ethnic, longitudinal Study of Women's Health Across the Nation, including repeated measurements of high-sensitivity C-reactive protein (hs-CRP), fibrinogen, tissue-type plasminogen activator antigen (tPA-ag), plasminogen activator inhibitor Type 1 (PAI-1), and Factor VIIc (Factor VII coagulant activity). We obtained residence-proximate PM2.5 and ozone monitoring data for a maximum five annual visits, calculating prior year, six-month, one-month, and one-day exposures and their relations to serum markers using longitudinal mixed models. Results For the 2,086 women studied from 1999 through 2004, PM2.5 exposures were associated with all blood markers except Factor VIIc after adjusting for age, race/ethnicity, education, site, body mass index, smoking, and recent alcohol use. Adjusted associations were of the strongest for prior year exposures for hs-CRP (21% increase per 10 μg/m3 PM2.5, 95% CI: 6.6, 37), tPA-ag (8.6%, 95% CI: 1.8, 16), and PAI-1 (35%, 95% CI: 19, 53). An association was also observed between year prior ozone exposure and Factor VIIc (5.7% increase per 10 ppb ozone, 95% CI: 2.9, 8.5). Conclusions Our findings suggest that prior year exposures to PM2.5 and ozone are associated with adverse effects on inflammatory and hemostatic pathways for cardiovascular outcomes in midlife women.

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“…Air pollution also has been associated with conduction and repolarization abnormalities which possibly increase the risk for PVCs (Van Hee et al, 2011). Furthermore, exposure to modest levels of air pollution have been shown to increase serum markers of inflammation which possibly alters myocardial substrate, leading to myocardial irritability (Adar et al, 2015). Additionally, the relationship between PM exposure and PVCs possibly depends on underlying myocardial vulnerability, such as the presence of coronary heart disease.…”

Section: Discussionmentioning

confidence: 99%

Fine particulate air pollution and premature ventricular contractions: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study

O’Neal

Soliman

Efird

et al. 2017

Environmental Research

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Background It is unknown if higher levels of ambient particulate matter (PM) exposure increase the risk for premature ventricular contractions (PVC) in a population-based study of men and women, and if this relationship varies by race or sex. Methods We examined the association of PM <2.5 micrometers in diameter (PM2.5) concentration with PVCs in 26,121 (mean age=64 ± 9.3 years; 55% female; 41% black) participants from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Estimates of short- (2-week) and long-term (1-year) PM2.5 exposures were computed prior to the baseline visit using geographic information system data on the individual level at the coordinates of study participants’ residences. PVCs were identified from baseline electrocardiograms. Results PVCs were detected in 1,719 (6.6%) study participants. Short- (OR=1.08, 95%CI=1.03, 1.14) and long- (OR=1.06, 95%CI=1.01, 1.12) term PM2.5 exposures were associated with PVCs. Interactions were not detected by race or sex. An interaction between short-term PM2.5 exposure and PVCs was detected for those with cardiovascular disease (OR=1.16, 95%CI=1.06, 1.27) compared with those without cardiovascular disease (OR=1.05, 95%CI=0.99, 1.12; p-interaction=0.027). Conclusion Our findings suggest that PM2.5 exposure is associated with an increased risk for PVCs in a biracial population-based study of men and women. We also have identified persons with cardiovascular disease as an at-risk population for PVCs when increases in short-term PM2.5 concentration occur.

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Markers of Inflammation and Coagulation after Long-Term Exposure to Coarse Particulate Matter: A Cross-Sectional Analysis from the Multi-Ethnic Study of Atherosclerosis

Cited by 31 publications

References 60 publications

Indoor Particulate Matter Associated with Systemic Inflammation in COPD

Indoor Particulate Matter Associated with Systemic Inflammation in COPD

Long-and Short-Term Exposure To Air Pollution and Inflammatory/Hemostatic Markers in Midlife Women

Fine particulate air pollution and premature ventricular contractions: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study

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