Markers of inflammation in schizophrenia: association vs. causation

QT dispersion and P wave dispersion in schizophrenia

“…The pathophysiological mechanism of the increased risk of CVD seen in schizophrenia is not fully known. The available evidence explains the common pathophysiological properties of severe mental diseases and CVD, such as hypothalamic-pituitaryadrenal axis dysfunction, mitochondrial dysfunction, peripheral immune activation, neuroinflammation, oxidative stress, and genetic connections [24]. It is not clear whether the high prevalence of CVD in schizophrenia originates from poor living conditions, antipsychotic treatment or from the schizophrenia itself.…”

What are the top 10 physical activity research questions in schizophrenia?

“…Recent systematic reviews of qualitative research considering the lived experience of patients have demonstrated that engaging in physical activity can improve confidence, reduce feelings of isolation and have a number of other important positive influences on bio-psychosocial outcomes [31,32]. Moreover, future research should explore the effects of physical activity interventions on other clinically relevant outcomes including inflammatory markers [10], pain [33], osteoporosis [34] and the risk for falls and fractures [35]. Finally, the effect of physical activity in youth experiencing their first episode psychosis is distinctly lacking [36] and requires further investigation.…”

“…For example, the most prevalent physical comorbidities contributing to the increased risk of premature mortality are cardio-metabolic [6,7] and respiratory diseases [8]. Although genetic factors [9] and shared pathophysiological mechanisms [10] contribute significantly to the high risk profile, unhealthy life style habits such as smoking [11], poor diet [12], and high levels of sedentary behavior and low levels of physical activity [13] play the most prominent role.…”

Schizophrenia and cytokines

“…Zanimljiv kritički osvrt na temu citokina, odnosno markera inflamacije i shizofrenije daje Manu i sar [49] u skoraš-njoj publikaciji kroz interesantan model koji služi pravilnijem sagledavanju da li neka povezanost može doprineti uzroku nekog patološkog fenomena. Model se sastojao iz nekoliko dimenzija: snaga i doslednost, prolaznost, stepen biološkog udela, uverljivost, koherentnost, specifič-nost inflamatornih abnormalnosti.…”