Markers of Liver function in rabbits (Oryctolagus cuniculus): Bark extracts of Nauclea latifolia and Alchornea cordifolia plants

Ogunrinola, Olabisi; Fajana, O.O.; Olaitan, Samuel; Adu, O. B.; Nuno, Millicent; Elemo, B. O.

doi:10.36108/jrrslasu/8102/50(0151)

Cited by 2 publications

(4 citation statements)

References 16 publications

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“…The presence of different bioactive constituents, such as flavonoids and tannins, that prevent the formation of lipid peroxide, thereby reducing the effect of co-existing substances or averting their oxidation, might be responsible for its mechanism of action. This is in accordance with some previous reports of some polyphenol-rich plant extracts such as Aspalathus linearis [11], Nauclea latifolia and Alchornea cordifolia [27], Salvia plebeia [47], and Hibiscus sabdariffa [48], among others, respectively.…”

Section: Discussionsupporting

confidence: 93%

“…When the membranes of liver cells become permeable, it results in an increase in blood concentrations of intracellular enzymes (aminotransferase (ALT) and aspartate aminotransferase (AST)) in the bloodstream, causing hepatocellular injury (e.g., hepatitis). And when there are obstructed or damaged intra-or extra-hepatic bile ducts, it causes the induction of the synthesis of alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGT), known as cholestasis (e.g., biliary obstruction or hepatic infiltration) [22,23,[24][25][26][27].…”

Section: Discussionmentioning

confidence: 99%

“…Current research supports several earlier reports that have shown that LPS induces hepatic damage, and therefore increases the concentrations of the aminotransferases (ALT, AST, ALP, and GGT) [11,[28][29][30][31][32][33]. The hepatic enzymes are cytoplasmic, and alteration in the membrane permeability will cause dysfunction and damaged structural integrity of hepatocytes and the aminotransferases to leak to the bloodstream, thereby resulting in an increase of the aminotransferases in the plasma of the male and female rat models, characterized by viral hepatitis, diabetes, heart failure, bile duct problems, haemorrhage, inflammation, cardiac, muscular, biliary, and injury, and microabscess formation, activation of the transcription factor nuclear factor-kappa B, and many inflammatory genes [11,27,28,30,33,[34][35][36][37].…”

Section: Discussionmentioning

confidence: 99%

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Therapeutic Role of Crinum glaucum Bulb against Haematological and Hepatic Enzyme Alterations in a Rat Model

Olatunji,

Ogunrinola,

Ogunrinola

et al. 2023

AJBGMB

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Aims: Several parts of medicinal plants have been known to have many health benefits. One of those plants is the Crinum glaucum (CG) bulb. Therefore, this research was undertaken to investigate the therapeutic role of an aqueous extract of CG bulb (aeCGb) against lipopolysaccharide (LPS)-induced haematological and hepatic enzyme alterations in male and female rat models. Study Design and Methodology: Twenty-five male and twenty-five female rats were divided randomly into five groups (n = 5) each. Group 1 is the control group. Group 2 was administered with 1000 mg/kg body weight of aeCGb. Group 3 was exposed to 4 ml/kg body weight of LPS for 4 hours. Group 4 was administered LPS (4 hours) and 1000 mg/kg body weight of aeCGb. Group 5 was administered 1000 mg/kg body weight of aeCGb and LPS for 4 hours. The albumin, total protein, bilirubin, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and gamma-glutamyl transferase (hepatic enzyme) concentrations and haematological parameters were analysed spectrophotometrically. Results: The hallmark of LPS is its ability to decrease the concentration of hepatic enzymes and the levels of haematological parameters, as observed. The levels of albumin, total protein, and direct and total bilirubin were significantly (P≤ .05) increased in the aeCGb-treated groups. However, treatment with aeCGb reverses the damaging effect of LPS on hepatic enzyme concentration. Conclusion: The results suggest that aeCGb has a therapeutic role in the LPS-induced alterations by correcting the concentration of hepatic enzyme function as well as regulating the levels of haematological parameters.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Therapeutic Role of Crinum glaucum Bulb against Haematological and Hepatic Enzyme Alterations in a Rat Model

Olatunji,

Ogunrinola,

Ogunrinola

et al. 2023

AJBGMB

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“…The blood was collected by cardiac puncture into heparinized tubes and the organs (brain, liver, kidney and heart) were excised. The blood, brain, liver, kidney and heart were processed as previously described by Ogunrinola et al [15,16]. All experiments were performed in acquiescence with the approval of the ad hoc Animal Ethical Committee of the Department of Biochemistry, Lagos State University, Ojo, Lagos-Nigeria and ethical guiding principles of laboratory animal care [17].…”

Section: Experimental Animals and Study Designmentioning

confidence: 99%

etiveria alliaceae EXTRACT HAD A PROTECTIVE IMPACT ON OXIDATIVE STRESS BIOMARKERS IN MALE RATS WITH LIPOPOLYSACCHARIDE-INDUCED ENDOTOXICITY

Ogunrinola

2022

JRRS

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Introduction: An imbalance between free radicals and antioxidants causes oxidative stress, which has detrimental consequences for a variety of health issues. Petiveria alliaceae (P. alliaceae) is a global plant having a variety of bioactive chemicals that have a variety of therapeutic uses. Aims: The objective of this study was to investigate the protective effect of P. alliaceae leaf aqueous extract on oxidative stress biomarkers in male rats with lipopolysaccharide (LPS) induced-endotoxicity. Materials and Methods: Twenty-five (25) male albino rats were divided into five (n = 5) groups at random. Group 1 was used as a control, Group 2 was given P. alliaceae aqueous extract (1000 mg/kg body weight), Group 3 was given LPS, a single intraperitoneal dose (4 ml/kg body weight), and was observed for 4 hours before being sacrificed, Group 4 was given LPS (observed for 4 hours) and treated with P. alliaceae for 7 days, Group 5 was given P. alliaceae extract for 7 days, then Spectrophotometric analysis was used to evaluate the activities of oxidative stress biomarkers (catalase (CAT) and superoxide dismutase (SOD) in plasma, erythrocytes, brain, liver, kidney, and heart. Results: As seen in this work, oxidative stress is a characteristic of LPS-induced endotoxicity. Following LPS injection, P. alliaceae leaf aqueous extract significantly (p 0.05) increased CAT and SOD activities. Conclusion The aqueous extract of P. alliaceae leaf reduced the effect of endotoxins in the body by mopping up free radicals, according to the findings

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Markers of Liver function in rabbits (Oryctolagus cuniculus): Bark extracts of Nauclea latifolia and Alchornea cordifolia plants

Cited by 2 publications

References 16 publications

Therapeutic Role of Crinum glaucum Bulb against Haematological and Hepatic Enzyme Alterations in a Rat Model

Therapeutic Role of Crinum glaucum Bulb against Haematological and Hepatic Enzyme Alterations in a Rat Model

etiveria alliaceae EXTRACT HAD A PROTECTIVE IMPACT ON OXIDATIVE STRESS BIOMARKERS IN MALE RATS WITH LIPOPOLYSACCHARIDE-INDUCED ENDOTOXICITY

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