Markers of malignant transformation of sinonasal inverted papilloma

Katori, Hideaki; Nozawa, Akio; Tsukuda, Mamoru

doi:10.1016/j.ejso.2005.05.014

Cited by 67 publications

(62 citation statements)

References 20 publications

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“…An immunohistochemical study has shown increased expression of p21 and p53 in inverted papillomas associated with dysplasia and squamous cell carcinoma [8]. HPV family 6/11 and 16/18 DNA has been observed in inverted papilloma associated with severe dysplasia and squamous cell carcinoma and HPV infection may be an early step in the process of malignant transformation [9]. An increased incidence of dysplasia has been observed in inverted papillomas positive for HPV family 6/11 and 16/18 DNA while decreased expression of p21 and p53 has been observed in HPV 16/18 positive inverted papillomas compared with those which are HPV 16/18 negative [8].…”

Section: Discussionmentioning

confidence: 99%

“…HPV infection has been shown to elevate EGFR levels by post translational mechanisms in keratinocytes and laryngeal papilloma cells [9]. Recently the muscle segment homeobox gene Msx2, implicated in the regulation of craniofacial bone metabolism, organ development and tumourigenesis has been demonstrated in inverted papillomas but not in normal tissue or inflammatory polyps.…”

Section: Discussionmentioning

confidence: 99%

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Common Head and Neck Cases in Our Consultation Referrals: Diagnostic Dilemmas in Inverted Papilloma

Sandison

2009

Head and Neck Pathol

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Papillomas of the nose and paranasal sinuses comprise three morphologically distinct variants-everted papilloma, inverted papilloma and cylindric cell papilloma in descending order of frequency. Recurrence of everted papilloma is unusual and malignant change does not occur. However, inverted papilloma is associated with multiple recurrences and malignant change. The histology of low grade squamous cell carcinoma of the nose may mimic that of inverted papilloma and low grade squamous cell carcinoma may coexist with inverted papilloma and be present in the same biopsy material. There is a high index of suspicion of concomitant malignancy in the presence of severe atypia or hyperkeratosis. Columnar cell papillomas are also associated with an increased risk of malignancy but the rarity of these lesions makes accurate assessment of malignant potential difficult. The most common diagnostic dilemma for pathologists referring cases for second opinion is the recognition of low grade malignancy versus benign inverted papilloma at presentation and in lesions which recur. Recent studies have addressed the requirement for histological parameters to predict the clinical course of these lesions and new molecular markers are being applied to tissue diagnosis. The early recognition and treatment of malignancy associated with inverted papilloma is key to decreased morbidity and improved patient survival and forms the basis of this discussion.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Common Head and Neck Cases in Our Consultation Referrals: Diagnostic Dilemmas in Inverted Papilloma

Sandison

2009

Head and Neck Pathol

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“…The immunohistochemical protein expression patterns of cell-cycle-regulators p53, p21, p27 and proliferation marker Ki-67 have been studied in IP and sinonasal carcinoma, which gave clues to this progression [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Öncel

Cosgul

Çallı

et al. 2011

Indian J Otolaryngol Head Neck Surg

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Using a molecular genetic approach, we try to confirm the molecular alterations of inverted papilloma and clarify its status as a putative precursor lesion of sinonasal squamous cell carcinoma. To better understand its genetics, we investigated the immunohistochemical protein expression patterns of cell-cycle-regulators p53, p63, p21, p27 and proliferation marker Ki-67 in 22 inverted papilloma and 9 squamous cell carcinoma of the sinonasal tract. Significantly elevated levels of p53 and p63 in squamous cell carcinoma of sinonasal tract compared with inverted papilloma were revealed. Ki-67-stained neoplastic cell nuclei were found in a significantly higher percentage of squamous cell carcinoma of sinonasal tract than in inverted papilloma, whereas no variation of p21 and p27 expression was identified. This work first examined the immunohistochemical overexpression of p63 in sinonasal inverted papilloma and squamous cell carcinoma. In conclusion, this is a first study shedding light on the expression of p63 in tumors of paranasal sinuses.

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“…It has been described that increased proliferative activity (Ki67) and loss of the expression of basal cell keratin 14 (CK 14) may predict recurrence [11]. Increased epidermal growth factor receptor (EGFR) and transforming growth factor-a (TGF-a) are thought to be early changes in IP transformation [12].…”

Section: Introductionmentioning

confidence: 99%

Fascin Over Expression is Associated with Dysplastic Changes in Sinonasal Inverted Papillomas: A Study of 47 Cases

Zafar

Huan

et al. 2009

Head and Neck Pathol

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Sinonasal inverted papilloma (IP) is a primary benign lesion with a tendency for local recurrence. Malignant transformation may develop in up to 15% of cases. Fascin (Fascin 1) is an actin cross-link binding protein required for the formation of actin-based cell-surface protrusions and cell motility. Fascin up-regulation in lung, gastric, breast and hepatobiliary carcinomas correlates with aggressiveness and decreased survival. Here we evaluate immunohistochemical expression of fascin in 47 sinonasal IPs from 34 patients. Fascin over-expression is significantly more common in sinonasal IP with high-grade dysplasia than in those with no dysplastic or low-grade dysplastic epithelium (P = 0.0001). No significant change in fascin expression is seen with recurrence. Over expression of fascin in high-grade dysplastic epithelium in IP may be associated with tumor progression and malignant transformation.

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Markers of malignant transformation of sinonasal inverted papilloma

Cited by 67 publications

References 20 publications

Common Head and Neck Cases in Our Consultation Referrals: Diagnostic Dilemmas in Inverted Papilloma

Common Head and Neck Cases in Our Consultation Referrals: Diagnostic Dilemmas in Inverted Papilloma

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Fascin Over Expression is Associated with Dysplastic Changes in Sinonasal Inverted Papillomas: A Study of 47 Cases

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