Markers of Oxidative Stress and Antioxidant Defense in Romanian Patients with Type 2 Diabetes Mellitus and Obesity

Abstract

Type 2 diabetes mellitus (T2DM) is strongly associated with obesity. The adipose tissue secretes bioactive adipokines leading to low grade inflammation, amplified by oxidative stress, which promotes the formation of advanced glycation end products and eventually leads to dyslipidemia and vascular complications. The aim of this study was to correlate anthropometric, biochemical and oxidative stress parameters in newly diagnosed (ND) T2DM patients and to investigate the role of oxidative stress in T2DM associated with obesity. A group of 115 ND- T2DM patients was compared to a group of 32 healthy subjects in terms of clinical, anthropometric, biochemical and oxidative stress parameters. ND-T2DM patients had significantly lower adiponectin, glutathione (GSH) and gluthatione peroxidase (GPx) and elevated insulin, proinsulin, HOMA-IR index, proinsulin/insulin (P/I) and proinsulin/adiponectin (P/A) ratio, fructosamine, and total oxidant status (TOS). The total body fat mass was positively correlated with total oxidant status (TOS). Positive correlations were found between TOS and glycated hemoglobin (HbA1c), and between TOS and glycaemia. Negative correlations were identified between: GPx and glycaemia, GPx and HbA1c, and also between GSH and fructosamine. The total antioxidant status was negatively correlated with the respiratory burst. The identified correlations suggest the existence of a complex interplay between diabetes, obesity and oxidative stress.

Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women

“…Similar findings of increased oxidant parameters and a decrease in antioxidants in patients with MetS have been reported in previous studies (19)(20)(21). However, there is a lack of information on the interaction between MetS and aging over the OxS status among elderly women.…”

“…However, there is a lack of information on the interaction between MetS and aging over the OxS status among elderly women. Previous studies in this area were predominantly conducted on individuals with multi-metabolic disorders (such as diabetes, hypertension, or hyperlipidemia) (8,14,16,20). By contrast, our study population sample had no metabolic or specific established diseases.…”

Potency of Cape Gooseberry (Physalis Peruviana) Juice in Improving Antioxidant and Adiponectin Level of High Fat Diet Streptozotocin Rat Model

“…Adiponectin level of K(-) in the end of study (11.9 mg/L) was considered as normal although it decreased 1.5%. Normal adiponectin level in normal subject is 7-12 mg/L [36]. Decreasing of adiponectin level in the end of study was postulated the standard diet laboratory Comfeed II containing low antioxidant that led adiponectin level decrease.…”

Total Antioxidant Status and Other Markers to Distinguish Severely Obese Volunteers with and without Metabolic Syndrome

“…This is supported by several reports on various risk factors of MetS, but none of them have organized the MetS on the basis of severity as assessed by z-score. Ravi Kiran et al [28] found a lower TAC in diabetic and MetS respondents, Picu et al [29], found low TAS along with low antioxidant enzymes, suggesting a strong association between T2DM and obesity, insulin resistance and OS, Bakhtiyari et al [30] reported a far greater effect of MetS than age on OS in senior women, as indicated by a strong correlation of high TG and low HDL-C, with MDA and TAC. Hopps et al [31] found significantly lower TAS in MetS non-diabetics but not in diabetic MetS respondents, and like us, they concluded that the evaluation of TAS may be a useful marker in the monitoring of MetS.…”