Markers of oxidative stress in postmenopausal women with metabolic syndrome

Montoya-Estrada, Araceli; Veruete-Bedolla, Daniela; Romo-Yáñez, José; Ortiz-Luna, Guillermo; Arellano-Eguiluz, Arturo; Nájera, Nayelli; Ceballos, Guillermo; Nieto-Velázquez, Nayeli Goreti; Ramos-Valencia, Ma. Abel; Cariño-Mancilla, Norma; Valdez-Rodríguez, Norma L.; Flores-Pliego, Arturo; Espejel-Núñez, Aurora; Reyes-Muñoz, Enrique

doi:10.1080/01443615.2022.2062223

Cited by 3 publications

(2 citation statements)

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“…Numerous research back up the idea that oxidant/antioxidant imbalance may be crucial for its symptoms. Blood samples from MS patients had higher levels of indicators for OS and lower levels of antioxidant defenses, which may indicate an overproduction of oxidizing species in-vivo ( 4 ). Minimally modified low-density lipoprotein (MM-LDL) and “(completely or extensively) oxidized” LDL are the two primary classifications used to characterize oxidized LDL (ox-LDL) ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress and metabolic diseases: Relevance and therapeutic strategies

et al. 2022

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Metabolic syndrome (MS) is a prominent cause of death worldwide, posing a threat to the global economy and public health. A mechanism that causes the oxidation of low-density lipoproteins (LDL) is associated with metabolic abnormalities. Various processes are involved in oxidative stress (OS) of lipoprotein. Although the concept of the syndrome has been fiercely debated, this confluence of risk factors is associated with a higher chance of acquiring type 2 diabetes mellitus (T2DM) and atherosclerosis. Insulin resistance has been found to play a significant role in the progression of these metabolism-associated conditions. It causes lipid profile abnormalities, including greater sensitivity to lipid peroxidation, contributing to the increased prevalence of T2DM and atherosclerosis. This review aims to cover the most recent scientific developments in dietary OS, the consequence of metabolic disorders, and their most significant clinical manifestations (T2DM and atherosclerosis). It will also emphasize the effects of dietary approaches in alleviating OS in MS.

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Section: Introductionmentioning

confidence: 99%

“…A drop in blood vitamin C and -tocopherol concentrations, a decline in superoxide dismutase (SOD) activity, and an increase in protein and lipid oxidation have all been linked to poor antioxidant defense in MS patients ( 4 ). On stopping OS in MS, several research is being conducted.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and metabolic diseases: Relevance and therapeutic strategies

et al. 2022

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Serum Endocan Levels in Postmenopausal Women with Metabolic Syndrome

Klisic,

Kotur-Stevuljevic,

Patoulias

et al. 2023

Metabolic Syndrome and Related Disorders

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Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome

Xu,

Lei,

Chu

et al. 2024

Front. Endocrinol.

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BackgroundThe oxidative balance score (OBS), an encompassing scoring mechanism for assessing oxidative stress, is formulated based on nutritional and lifestyle components. The emergence of metabolic syndrome (MetS) is intricately linked to oxidative stress. Nonetheless, the correlation between OBS and MetS displays variability within distinct cohorts.ObjectiveWe worked on the relationships between OBS and the risk of MetS, MetS severity, and all-cause mortality of MetS patients.MethodsA total of 11,171 adult participants were collected from the U.S. National Health Examination Survey (NHANES) 2007-2018. Employing survey-weighted logistic models, we evaluated the relationship between OBS and MetS risk. Furthermore, survey-weighted linear models were utilized to investigate the connection between OBS and MetS severity. Among the participants, 3,621 individuals had their survival status recorded, allowing us to employ Cox proportional hazards regression models in order to ascertain the association between OBS and the all-cause mortality within the subset of individuals with MetS. The OBS (where a higher OBS signified an increased prevalence of anti- or pro-oxidant exposures) weighed the 20 factors, while the MetS severity score weighed the five factors.ResultsAfter multivariable adjustment, individuals with elevated OBS were found to exhibit a decreased susceptibility to MetS [odds ratio (OR) 0.95; 95% CI 0.94-0.96]. The adjusted OR was 0.42 (95% CI 0.33-0.53) for MetS risk in the fourth OBS quartile compared with those in the first OBS quartile (P for trend < 0.001). A one-unit increase in OBS was linked to a 3% reduction in MetS severity score by 3% (mean difference, -0.03; 95% CI, -0.04 to -0.03). Moreover, increased OBS correlated with decreased hazard of all-cause mortality risk among MetS subjects (adjusted hazard ratio, 0.95; 95% CI, 0.93-0.98). These associations retained their strength even subsequent to the introduction of sensitivity analyses. There existed a statistically significant negative correlation between diet/lifestyle OBS and both MetS risk as well as MetS severity.ConclusionsAn inverse correlation was observed between OBS and the susceptibility to MetS, MetS severity, and all-cause mortality of MetS patients. Health outcomes for MetS patients were positively related to antioxidant diets and lifestyles.

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Markers of oxidative stress in postmenopausal women with metabolic syndrome

Cited by 3 publications

References 43 publications

Oxidative stress and metabolic diseases: Relevance and therapeutic strategies

Oxidative stress and metabolic diseases: Relevance and therapeutic strategies

Serum Endocan Levels in Postmenopausal Women with Metabolic Syndrome

Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome

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