Markers of preeclampsia

OBESITY-RELATED PRE-ECLAMPSIA - FETUS AND NEWBORN OUTCOMES (literature review)

“…Increased adma concentrations are associated with inflammation, insulin resistance, dyslipidemia, obesity and cardiovascular diseases. Interestingly, the circulating adma, as shown, decreases with weight loss [30]. In several studies, higher concentrations of ADMA were demonstrated with preeclampsia and even before its development [10].…”

“…Many of these factors are associated with preeclampsia, thus increasing the likelihood of the presence of some general pathogenetic mechanisms of obesity and preeclampsia, which contribute to an increase in preeclampsia. Violation of the synthesis of nitrogen oxide (NO) and bioavailability leading to vascular dysfunction -the general key mechanism of the pathogenesis of obesity and cardiovascular diseases [30]. Asymmetric dimethylarginin (ADMA) is a competitive agonist L-Arginin, the precursor of the synthesis of nitrogen oxide.…”