“…Deleterious effects of such a transformation on rat embryos at the initial stages of organogenesis have been demonstrated for cyclophosphamide, ethanol, adriamycin, and other compounds [2,3,5]. Recent studies show that metabolic activation of some substances, specifically, polycyclic aromatic hydrocarbons (PAH), aromatic amines, and dioxines occurs not only in mother's body, but also in embryos at the early stages of prenatal life [6,7].…”