PurposeThe study aims to evaluate the long- vs short-run relationships between crops' production (output) and crops' significant inputs such as land use, agricultural water use (AWU) and gross irrigated area in India during the period 1981–2018.Design/methodology/approachThe study applied the autoregressive distributed lag (ARDL) bounds testing approach to estimate the co-integration among the variables. The study uses the error correction model (ECM), which integrates the short-run dynamics with the long-run equilibrium.FindingsThe ARDL bounds test of co-integration confirms the strong evidence of the long-run relationship among the variables. Empirical results show the positive and significant relationship of crops' production with land use and gross irrigated area. The statistically significant error correction term (ECT) validates the speed of adjustment of the empirical models in the long-run.Research limitations/implicationsThe study suggests that the decision-makers must understand potential trade-offs between human needs and environmental impacts to ensure food for the growing population in India.Originality/valueFor a clear insight into the impact of climate change on crops' production, the current study incorporates the climate variables such as annual rainfall, maximum temperature and minimum temperature. Further, the study considered agro-chemicals, i.e. fertilizers and pesticides, concerning their negative impacts on increased agricultural production and the environment.