This article links two different fields of research, entrepreneurship and cooperatives, and studies whether, depending on the context, differences in terms of the fulfilment of the cooperative philosophy (cooperative essence) and entrepreneurial quality exist. To this aim, a statistical analysis is carried out using data from two Spanish regions: Andalusia and the Basque Country. The results enable us to conclude, firstly, that cooperative essence differs in relation to regional context, but not in relation to entrepreneurial quality. Secondly, cooperative essence and entrepreneurial quality are positively related, suggesting that cooperative essence may be part of the entrepreneurial quality of these kinds of firms.