The article actualizes the problem of post-crisis resumption of activity of industrial enterprises of Ukraine in the post-war period. It is argued that this requires systemic transformations of the business model based on the implementation of relevant innovation strategies. The results of the analysis of innovative activity of industrial enterprises of Ukraine for 2014-2020 are presented and correlated with the dynamics of the corresponding costs. The low return on innovation is indicated. It is assumed that this is a consequence of the fact that in the formation of targets of innovation strategies, preference is given to indicators of allocative efficiency. The shortcomings of this approach are pointed out, the main of which is the lack of efficiency in the implementation of innovative changes, caused by the inconsistency of the structure of the innovative potential of the enterprise to the goals of innovative development. This causes the company to lag behind the schedule of innovative changes and threatens it with the loss of dynamic stability during the implementation of innovation strategies. The need to form a relevant theoretical and methodological basis to justify the choice of industrial enterprise innovation strategy, able to ensure the systemic transformation processes in conjunction with the goals of increasing competitiveness in the strategic period. The need to combine allocative and adaptive efficiency indicators in the formation of goals of innovative change is emphasized and the priority is given to the priority of ensuring adaptive efficiency. The author’s position is expressed that the methodological basis for the development of innovative strategies of industrial enterprises should be an anticipatory approach in management. It is argued that this requires high information sensitivity in the decision-making system, which is achieved by decentralization of management. The algorithm of substantiation of decisions in the system of decentralized management of system transformations of the enterprise on the basis of realization of innovative strategies is developed.