Marriage of artificial catalase and black phosphorus nanosheets for reinforced photodynamic antitumor therapy

Ouyang, Jun; Deng, Yuanyuan; Chen, Wansong; Xu, Qingsong; Liu, Zhenjun; Tang, Feiying; Liu, Deng

doi:10.1039/c8tb00371h

Cited by 63 publications

(60 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[20] Forn ormal cell mitochondria, the high MMP causes JC-1 to form red fluorescent aggregates.O nce mitochondria are damaged, their MMP will be decreased, and they will be stained by green fluorescent monomeric JC-1. Cell apoptosis has been reported to be associated with mitochondrial dysfunction.…”

mentioning

confidence: 99%

“…Cell apoptosis has been reported to be associated with mitochondrial dysfunction. [20] Forn ormal cell mitochondria, the high MMP causes JC-1 to form red fluorescent aggregates.O nce mitochondria are damaged, their MMP will be decreased, and they will be stained by green fluorescent monomeric JC-1. Fort he cells treated with PEG@GeQDs alone or NIR laser only,t he fluorescence ratio of green/red (G/R) was about 0.09, which was nearly the same as that of the control cells (Figure 3fand Supporting Information, Figure S10).…”

mentioning

confidence: 99%

See 1 more Smart Citation

2D Monoelemental Germanene Quantum Dots: Synthesis as Robust Photothermal Agents for Photonic Cancer Nanomedicine

Ouyang

Feng

et al. 2019

Angewandte Chemie

Self Cite

View full text Add to dashboard Cite

As an ew family member of the emerging twodimensional (2D) monoelemental materials (Xenes), germanene has shown promising advantages over the prototypical 2D Xenes,s uch as black phosphorus (BP) and graphene. However,e fficient manufacture of novel germanene nanostructures is still ac hallenge.H erein, as imple top-down approach for the liquid-exfoliation of ultra-small germanene quantum dots (GeQDs) is presented. The prepared GeQDs possess an average lateral size of about 4.5 nm and thickness of about 2.2 nm. The functionalizedG eQDs were demonstrated to be robust photothermal agents (PTAs) with outstanding photothermal conversion efficacy (higher than those of graphene and BPQDs), superior stability,a nd excellent biocompatibility.A saproof-of-principle,2 DG eQDs-based PTAs were used in fluorescence/photoacoustic/photothermalimaging-guided hyperpyrexia ablation of tumors.T his work could expand the application of 2D germanene to the field of photonic cancer nanomedicine.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

2D Monoelemental Germanene Quantum Dots: Synthesis as Robust Photothermal Agents for Photonic Cancer Nanomedicine

Ouyang

Feng

et al. 2019

Angewandte Chemie

Self Cite

View full text Add to dashboard Cite

show abstract

“…To confirm our hypothesis, we studied their performance in regulating intracellular oxidative stress with 2′,7′‐dichlorofluorescin diacetate (DCFH‐DA) as a probe. The nonfluorescent DCFH‐DA can be converted into highly fluorescent 2′,7′‐dichlorofluorescein (DCF) under intracellular oxidative stress . Compared with cells in the control group, cells treated by Cu 2− x Te NEs show a sevenfold increase of intracellular fluorescence intensity.…”

Section: Resultsmentioning

confidence: 99%

“…Then onfluorescent DCFH-DAc an be converted into highly fluorescent 2',7'-dichlorofluorescein (DCF) under intracellular oxidative stress. [14] Compared with cells in the control group,cells treated by Cu 2Àx Te NEs show asevenfold increase of intracellular fluorescence intensity.A fter NIR-II light irradiation for 5minutes,t he oxidative stress induced by Cu 2Àx Te NEs is further enhanced by 1.7-fold as compared to that without irradiation (Figures 3a and b). However,NIR-II light itself shows little influence on the intracellular oxidative stress.C ollectively,a ll the above results validate the augmented generation of oxidative stress by Cu 2Àx Te NEs under NIR-II light.…”

Section: Angewandte Chemiementioning

confidence: 92%

Artificial Enzyme Catalyzed Cascade Reactions: Antitumor Immunotherapy Reinforced by NIR‐II Light

et al. 2019

Self Cite

View full text Add to dashboard Cite

Current cancer therapy is seriously challenged by tumor metastasis and recurrence. One promising solution to these problems is to build antitumor immunity. However, immunotherapeutic efficacy is highly impeded by the immunosuppressive state of the tumors. Here a new strategy is presented, catalytic immunotherapy based on artificial enzymes. Cu2−xTe nanoparticles exhibit tunable enzyme‐mimicking activity (including glutathione oxidase and peroxidase) under near‐infrared‐II (NIR‐II) light. The cascade reactions catalyzed by the Cu2−xTe artificial enzyme gradually elevates intratumor oxidative stress to induce immunogenic cell death. Meanwhile, the continuously generated oxidative stress by the Cu2−xTe artificial enzyme reverses the immunosuppressive tumor microenvironment, and boosts antitumor immune responses to eradicate both primary and distant metastatic tumors. Moreover, immunological memory effect is successfully acquired after treatment with the Cu2−xTe artificial enzyme to suppress tumor relapse.

show abstract

“…Superior strides in antitumor strategies have modestly improved the clinical outcomes, the mortality of tumor still remains high owing to tumor recurrence and metastasis. [1][2][3][4][5][6][7][8] Immunotherapy has been well concerned due to its function of controlling the development of distant metastatic tumor. [9][10][11] In particular, checkpoint inhibitors and chimeric antigen receptor T-cell immunotherapy have been regarded as crucial tools for cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

<p>Combinational phototherapy and hypoxia-activated chemotherapy favoring antitumor immune responses</p>

Sheng

Wang

et al. 2019

IJN

View full text Add to dashboard Cite

Background: Tumor metastasis is responsible for most cancer death worldwide, which lacks curative treatment. Purpose: The objective of this study was to eliminate tumor and control the development of tumor metastasis. Methods: Herein, we demonstrated a smart nano-enabled platform, in which 2-[2-[2-chloro-3-[(1,3-dihydro-3,3-dimethyl-1-propyl-2h-indol-2-ylidene)ethylidene]-1-cyclohexen-1-yl]ethenyl]-3,3-dimethyl-1-propylindolium iodide (IR780) and tirapazamine (TPZ) were co-loaded in poly(ε-caprolactone)-poly(ethylene glycol) (PEG-PCL) to form versatile nanoparticles (PEG-PCL-IR780-TPZ NPs). Results: The intelligence of the system was reflected in the triggered and controlled engineering. Specially, PEG-PCL not only prolonged the circulation time of IR780 and TPZ but also promoted tumor accumulation of nanodrugs through enhanced permeability and retention (EPR) effect. Moreover, reactive oxygen species (ROS) generated by IR780 armed by an 808 nm laser irradiation evoked a cargo release. Meanwhile, IR780, as a mitochondria-targeting phototherapy agent exacerbated tumor hypoxic microenvironment and activated TPZ for accomplishing hypoxia-activated chemotherapy. Most significantly, IR780 was capable of triggering immunogenic cell death (ICD) during the synergic treatment. ICD biomarkers as a “danger signal” accelerated dendritic cells (DCs) maturation, and subsequently activated toxic T lymphocytes. Conclusion: Eventually, antitumor immune responses stimulated by combinational phototherapy and hypoxia-activated chemotherapy revolutionized the current landscape of cancer treatment, strikingly inhibiting tumor metastasis and providing a promising prospect in the clinical application.

show abstract

Marriage of artificial catalase and black phosphorus nanosheets for reinforced photodynamic antitumor therapy

Abstract: Pt nanoparticle-based artificial catalase is decorated on black phosphorus nanosheets, achieving reinforced photodynamic antitumor performance.

Cited by 63 publications

References 31 publications

2D Monoelemental Germanene Quantum Dots: Synthesis as Robust Photothermal Agents for Photonic Cancer Nanomedicine

2D Monoelemental Germanene Quantum Dots: Synthesis as Robust Photothermal Agents for Photonic Cancer Nanomedicine

Artificial Enzyme Catalyzed Cascade Reactions: Antitumor Immunotherapy Reinforced by NIR‐II Light

<p>Combinational phototherapy and hypoxia-activated chemotherapy favoring antitumor immune responses</p>

Contact Info

Product

Resources

About