Marrow infarction in sickle cell anemia: Correlation with marrow type and distribution by MRI

Rao, Vijay M.; Mitchell, Donald G.; Rifkin, Matthew D.; Steiner, Robert M.; Burk, D L; Levy, David; Ballas, Samir K.

doi:10.1016/0730-725x(89)90322-6

Cited by 37 publications

(11 citation statements)

References 11 publications

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“…However, sickle patients exhibit erythropoietic hyperplasia resulting in the maintenance of and reconversion to red marrow [Mankad et al, 1990]. Moreover, marrow infarctions due to crises occur more frequently in the red marrow than in yellow [Rao et al, 1989]. …”

Section: Introductionmentioning

confidence: 99%

Microarchitectural and mechanical characterization of the sickle bone

Green

Akinsami

Lin

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

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Individuals with sickle cell disease often experience acute and chronic bone pain due to occlusive events within the tissue vasculature that result in ischemia, necrosis, and organ degeneration. Macroscopically, sickle bone is identified in clinical radiographs by its reduced mineral density, widening of the marrow cavity, and thinning of the cortical bone due to the elevated erythroid hyperplasia accompanying the disease. However, the microstructural architecture of sickle bone and its role in mechanical functionality is largely unknown. This study utilized micro-CT and biomechanical testing to determine the relationship between the bone morphology, tissue mineral density, and trabecular and cortical microarchitecture of 10-and 21-week-old femurs from transgenic sickle male mice and littermates with sickle trait, as well as a wild-type control. While bone tissue mineral density did not vary among the genotypes at either age, variation in bone microstructure were observed. At 10 weeks, healthy and trait mice exhibited similar morphology within the cortical and trabecular bone, while sickle mice exhibited highly connected trabeculae. Within older femurs, sickle and trait specimens displayed significantly fewer trabeculae, and the remaining trabeculae had a more deteriorated geometry based on the structure model index. Thinning of the cortical region in sickle femurs contributed to the displayed flexibility with a significantly lower elastic modulus than the controls at both 10- and 21-weeks old. Wild-type and trait femurs generally demonstrated similar mechanical properties; however, trait femurs had a significantly higher modulus than sickle and wild-type control at 21-weeks. Overall, these data indicate that the progressive damage to the microvasculature caused by sickle cell disease, results in deleterious structural changes in the bone tissue's microarchitecture and mechanics.

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Section: Introductionmentioning

confidence: 99%

Microarchitectural and mechanical characterization of the sickle bone

Green

Akinsami

Lin

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

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“…Bone scan with technetium 99m Tc and magnetic resonance imaging (MRI) can detect disease but these tests are very expensive and difficult to use routinely in a developing country like Nigeria (David et al, 1993;Ballas, 1995;Ballas 2001;Smith, 1996;Rao et al, 1985;Rao et al, 1989;Amundsen et al, 1984;Milner et al, 1993;Mitchell et al, 1987). Recently there has been introduction of new biochemical markers of bone metabolism such as osteocalcin and others (Bettica and Moro, 1995;Kleerekoper 1997;De la Piedra et al, 1996;Bolarin, 1996).…”

Section: Introductionmentioning

confidence: 99%

“…The sickle cell disease is a cause of hip deformities in the patients (David et al, 1993;Ballas, 1995;Ballas 2001;Smith, 1996;Lee, et al, 1981;Embury et al, 1994;Francis and Johnson, 1991;Hebbel, 1991;Powars, 1990). Involvement of the humeral head is also very common (Rao et al, 1985;Rao et al, 1989;Amundsen et al, 1984;Milner et al, 1993;Mitchell et al, 1987). More than 30 percent of patients with sickle cell disorders end up with complications of avascular necrosis of the bone (David et al, 1993;Ballas, 1995;Ballas 2001;Smith, 1996).…”

Section: Introductionmentioning

confidence: 99%

“…Avascular necrosis is the commonest and a major chronic complication of sickle cell disorders (David et al, 1993;Ballas, 1995;Ballas 2001;Smith, 1996;Mitchell et al, 1986;Rao et al, 1985;Rao et al, 1989;Amundsen et al, 1984;Milner et al, 1993;Mitchell et al Nigerian Journal Of Physiological Sciences 21 (1-2): 21-25 ©Physiological Society Of Nigeria, 2006Nigeria, 1987). The sickle cell disease is a cause of hip deformities in the patients (David et al, 1993;Ballas, 1995;Ballas 2001;Smith, 1996;Lee, et al, 1981;Embury et al, 1994;Francis and Johnson, 1991;Hebbel, 1991;Powars, 1990).…”

Section: Introductionmentioning

confidence: 99%

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Osteocalcin and bone-specific alkaline phosphatase in Sickle cell haemoglobinopathies

Azinge¹,

Bolarin²

2010

Nig. J. Phys Sci

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Summary:Osteocalcin or bone gamma-carboxyglutamic acid (gla) protein and Bone-specific alkaline phosphatase (b-AP) total protein levels were evaluated as indicators of bone turnover in twenty patients with sickle cell haemoglobinopathies and in twenty normal healthy individuals. The serum bonespecific alkaline phosphatase total protein level was measured by immunoradiometric (IRMA) method. The concentrations of serum bone-specific alkaline phosphatase total protein were higher in the study group than in the control group (p < 0.05). The serum osteocalcin (BGP) showed no significant difference with the control healthy subjects. There was no correlation between the serum osteocalcin and serum bone-specific alkaline phosphatase total protein in the patient group. In conclusion, serum bone-specific alkaline phosphatase total protein determined or measured by IRMA can be considered a sensitive marker of bone turnover and could be especially useful as valuable non-invasive biochemical marker for identifying sickle cell patients with bone complications.

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“…24 in a previous MR imaging study of marrow infarct in 11 patients with sickle cell anemia, Rao et al 1986. 25 showed a strong direct correlation between marrow edema and pain.…”

Section: Discussionmentioning

confidence: 99%

Mri in Diagnosis and Evaluation of Avn of Femoral Head in Sickle Cell Disease and Comparison With Plain X Ray

Netam¹,

Singh²,

Bichpuria³

et al. 2015

jemds

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OBJECTIVE:To assess the role of MRI in cases of AVN of femoral head in sickle cell disease in comparison to x-ray. MATERIAL AND METHODS: 55 patients (110 hip joints) who were suffering from sickle cell disease (Confirmed by HB electrophoresis) & with complain' of pain in one or both hip joints, were examined by plain x-ray and 0.2 tesla MRI, using T1W (350ms/17ms), T2W (2200ms/110ms) and STIR (4000ms/80ms/90) sequences in axial, coronal and sagittal planes.

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Marrow infarction in sickle cell anemia: Correlation with marrow type and distribution by MRI

Cited by 37 publications

References 11 publications

Microarchitectural and mechanical characterization of the sickle bone

Microarchitectural and mechanical characterization of the sickle bone

Osteocalcin and bone-specific alkaline phosphatase in Sickle cell haemoglobinopathies

Mri in Diagnosis and Evaluation of Avn of Femoral Head in Sickle Cell Disease and Comparison With Plain X Ray

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