Marrow Iron Examination in the Diagnosis of Iron Deficiency in Rheumatoid Arthritis

McCrea, P. C.

doi:10.1136/ard.17.1.89

Cited by 20 publications

(6 citation statements)

References 23 publications

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“…Thus the anemia of chronic disorders develops in most patients with RA of a certain disease activity, and iron deficiency has been observed in 30-70% of patients (17,19,20). The anemia is rarely so severe as to cause symptoms.…”

Section: Serum Ferritin and The Assessment Of Iron Deficiency In Rheumentioning

confidence: 98%

Serum Ferritin and the Assessment of Iron Deficiency in Rheumatoid Arthritis

Hansen

et al. 1983

Scandinavian Journal of Rheumatology

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In order to evaluate the diagnostic and pathogenetic importance of s-ferritin and p-lactoferrin in the anemia of rheumatoid arthritis (RA), 38 patients were examined. Twenty-one out of 38 randomly selected anemic patients with classical or definite RA had iron deficiency, as estimated from the iron content in stained bone marrow aspiration. S-ferritin concentrations below 60 micrograms per litre had sensitivity and a specificity for iron deficiency of 86% and 88%, respectively, which was much better than such commonly used variables as s-iron, p-transferrin, MCV, and MCHC. Although this cut-off level is higher than in patients without inflammatory disease, s-ferritin was not correlated to disease activity. In 7 out of 8 patients, the s-ferritin level rose during iron therapy. P-lactoferrin values were within the normal range and did not vary with the anemia or with disease activity. Thus p-lactoferrin appears to be of no pathogenetic importance in the anemia of RA.

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Section: Serum Ferritin and The Assessment Of Iron Deficiency In Rheumentioning

confidence: 98%

Serum Ferritin and the Assessment of Iron Deficiency in Rheumatoid Arthritis

Hansen

et al. 1983

Scandinavian Journal of Rheumatology

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“…We found empty iron bone marrow stores in only 20 % of 65 arthritic patients (unpublished study) determined using histochemical and chemical methods (Johansson, Plantin, Strandberg, and Uusma, 1970). According to the literature (Richmond, Gardner, Roy, and Duthie, 1956;McCrea, 1958;Weinstein, 1959;Jeffrey, 1961), the frequency of empty bone marrow iron stores lies between 0 and 50% in patients with rheumatoid arthritis.Heilmeyer (1964) reported increased urinary excretion of S-aminolevulinic acid (ALA) and …”

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confidence: 63%

Haem biosynthesis studied in patients with rheumatoid arthritis

Johansson¹,

Strandberg²

1972

J Clin Pathol

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SYNOPSIS In a study of the urinary excretion of haem precursors in patients with rheumatoid arthritis, iron-deficiency anaemia, and in healthy controls, certain differences were found.In iron-deficiency anaemia the excretion of both porphobilinogen and &-aminolevulinic acid was increased, whereas in patients with rheumatoid arthritis only the porphobilinogen excretion was increased.A further study on the erythrocyte activity of a-aminolevulinic acid dehydrase showed a higher activity in the erythrocytes from patients with rheumatoid arthritis compared with healthy controls.In most of the literature concerning inflammatory anaemias a distinction is made from uncomplicated iron-deficiency anaemia (Nilsson, 1948;Jeffrey, 1953; Cartwright, 1968 Gardner, Roy, and Duthie, 1956;McCrea, 1958;Weinstein, 1959;Jeffrey, 1961), the frequency of empty bone marrow iron stores lies between 0 and 50% in patients with rheumatoid arthritis.Heilmeyer (1964) reported increased urinary excretion of S-aminolevulinic acid (ALA) and

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“…It seems possible that this relationship may explain the variable results of the administration of iron to patients with rheumatoid arthritis (Sinclair andDuthie, 1949, 1950;Ross, 1950;Jeffrey, 1952, 1953a andb;Millard and Barber, 1956;McCrea, 1958;Richmond and others, 1958).…”

Section: Discussionmentioning

confidence: 99%