Marrow macrophages—pharmacologic sanctuary for pluripotent stem cells?

Janković, Gradimir; Čolović, Milica; Colović, R; Novak, Atara; Antonijević, Nebojša; Bogdanović, A; Rolović, Z

doi:10.1016/0145-2126(94)90012-4

Cited by 2 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One could hypothesize that the number of circulating clonogenic precursors way increase with the terminal progression of splenic metaplasia with the elective splenectomy or splenic irradiation resulting in their decrease in the blood (14)(15)(16). This may be due to elimination of the large splenic phagocyte mass which may serve as an emperipoletic asylum for the haemopoietic stem cells (17). Alternatively, removal of metaplastic splenic haemopoietic tissue, wherefrom clonogenic precursors originate, reduces the level of circulating precursors in a direct manner.…”

Section: Discussionmentioning

confidence: 99%

Circulating haemopoietic progenitor cells in primary and secondary myelofibrosis: relation to collagen and reticulin fibrosis

Čolović¹,

Wiernik

Janković³

et al. 1999

European J of Haematology

View full text Add to dashboard Cite

The relationship between the extent of bone marrow reticulin and collagen fibrosis and the concentration of granulocytic (CFU–GM), erythroid (BFU–E) and megakaryocyte (CFU–Mk) progenitor cells in the peripheral blood of patients with primary agnogenic myeloid metaplasia (AMM) and secondary myelofibrosis (sMF) has not been definitively correlated. We studied 23 patients with established diagnosis of AMM and 12 patients with sMF for the extent of reticulin and collagen bone marrow fibrosis and for the spontaneous colony (sCFU–GM, sBFU–E and sCFU–Mk) formation. The control group consisted of 11 healthy volunteers. Trephine biopsy of the posterior iliac crest was performed in all individuals studied to determine the type and degree of reticulin and collagen fibrosis. Gomori's silver impregnation technique was used. sCFU–GM, sBFU–E and sCFU–Mk colony formation was related positively to spleen size, the white blood cell counts and the degree of collagen fibrosis in AMM (p < 0.01). Stimulated CFU–GM were also significantly correlated with the degree of bone marrow reticulin and collagen fibrosis. There was no correlation between the extent of peripheral blood progenitor concentration and the degree of bone marrow reticulin or collagen fibrosis in sMF and in control individuals. In conclusion, the extent of bone marrow fibrosis is significantly correlated with the peripheral blood progenitor colony formation in AMM but not in sMF.

show abstract

Section: Discussionmentioning

confidence: 99%