Marrow transplantation from tolerant donors to treat and prevent autoimmune diseases in BXSB mice.

Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?

“…[311][312][313][314][315][316][317][318][319][320][321] Murine spontaneous-onset lupuslike disease is cured by allogeneic HSCT from a normal donor strain. 311,314,315,317 Spontaneous-onset diabetes in NOD mice is prevented by allogeneic HSCT from a nondiabetic prone strain 316,319,321 and cured by combined pancreas and allogeneic HSCT from the same donor. 318 In fact, the "tolerizing" effect 322,323 of HSCs is best demonstrated by donor-specific organ tolerance when combining solid organ and marrow transplant from the same donor.…”

Nonmyeloablative allogeneic bone marrow transplantation of a child with systemic autoimmune disease and lung vasculitis

“…The initial studies in the 1970s and 1980s represented a quest to explore the origins of autoimmune diseases by using murine models, including BXSB [12][13][14][15][16][17]. In these models, it was clearly shown that the genetic information encoded in the hematopoietic stem cells is a major determinant for the development of an autoimmune phenotype distinct from defects associated with thymus, hormones, or toxic agents [16,17]. The concept of mixed chimerism for control of autoimmune diseases was first presented by Dr. Good in the 1990s [18,19].…”

Acute immunosuppression and syngeneic bone marrow transplantation in ocular autoimmunity abort disease, but do not result in induction of long-term protection

“…[23][24][25][26][27] These studies emphasize the potential value of such combined procedures for treatment of intractable autoimmune diseases. Nevertheless, there is substantial risk involved in an allogeneic procedure in which the host's immune cells are replaced by a normal donor-type immune system.…”