Oral
friction on the tongue surface plays a pivotal role in mechanics
of food transport, speech, sensing, and hedonic responses. The highly
specialized biophysical features of the human tongue such as micropapillae-dense
topology, optimum wettability, and deformability present architectural
challenges in designing artificial tongue surfaces, and the absence
of such a biomimetic surface impedes the fundamental understanding
of tongue–food/fluid interaction. Herein, we fabricate for
the first time, a 3D soft biomimetic surface that replicates the topography
and wettability of a real human tongue. The 3D-printed fabrication
contains a Poisson point process-based (random) papillae distribution
and is employed to micromold soft silicone surfaces with wettability
modifications. We demonstrate the unprecedented capability of these
surfaces to replicate the theoretically defined and simulated collision
probability of papillae and to closely resemble the tribological performances
of human tongue masks. These de novo biomimetic surfaces pave the
way for accurate quantification of mechanical interactions in the
soft oral mucosa.