This paper presents a novel adaptive sliding-mode control (ASMC) method for Mars entry guidance and the finite-time convergence in the presence of large uncertainties can be guaranteed. With the help of gain adaptive law, the nonoverestimating value of control gains can be achieved, and then, the chattering can be attenuated by the proposed ASMC method. Meanwhile, the extended state observer is introduced to estimate and compensate for uncertainties and the nonoverestimating problem is resolved further. In addition, the proposed method does not require any knowledge on the upper bound of uncertainty, which yields to be used in practical systems. Finally, the numerical simulation results are given to demonstrate the effectiveness of the proposed guidance law.