We present a theoretical study about the influence of magneto‐crystalline anisotropies on the static and dynamic magnetic properties of trilayers coupled via bilinear and biquadratic exchange fields for situations in which the systems are grown in unusual [hkl] low‐symmetry directions. We apply a realistic phenomenological model, with a total free magnetic energy that includes Zeeman interaction and magneto‐crystalline anisotropies as well as exchange energy terms. We consider parameters from the literature to illustrate our results for Fe/Cr/Fe systems. In particular, a total of six different magnetic scenarios for the [211] and [321] low‐symmetry growth orientations and three sets of exchange fields were analyzed, and the associated magnetization, magnetoresistance, and spin‐wave frequencies were calculated. Our results show that the combination of magneto‐crystalline symmetries and exchange fields leads to various interesting properties, including different values of the saturation field for the magnetization and magnetoresistance curves. Regarding the spin‐wave modes, we observed the presence of Goldstone modes, associated with second‐order phase transitions, resulting from the competition between the Zeeman and biquadratic energies.