Mask-Like Metastasis: Report of 2 Cases of 4 Eyelid Metastases and Review of the Literature

Martorell, A.; Requena, Celia; Díaz-Recuero, José Luis; Haro, Rosario; Sarasa, José Luis Andrès; Sanmartín, O.; Botella‐Estrada, Rafael; Calderón, Mar Burgués; Barona, Carlos Guillén; Requena, Luís

doi:10.1097/dad.0b013e3181a903c4

Cited by 19 publications

(16 citation statements)

References 16 publications

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“…The most common primary tumor is breast carcinoma (40–50%), followed by cutaneous gastro‐enteric, urogenital, respiratory tract, and choroid malignancies. In 8–11% of cases, the origin of the neoplasm remains unknown . Unilateral presentation, involving the right and left eyelid in equal proportion, is more common than bilateral involvement, which is exceedingly rare.…”

Section: Discussionmentioning

confidence: 99%

Monocle and mask‐like metastasis: two cases of eyelid metastasis from breast carcinoma – role of isotopic phenomenon?

Rongioletti

2014

Int J Dermatology

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Section: Discussionmentioning

confidence: 99%

Monocle and mask‐like metastasis: two cases of eyelid metastasis from breast carcinoma – role of isotopic phenomenon?

Rongioletti

2014

Int J Dermatology

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“…48 The most frequent type is the nodular pattern (up to two-thirds of all cases), which is characterized by painless, subcutaneous, skin-colored nodules that are often clinically mistaken with chalazion. This variant has been named mask-like metastasis 50 (Fig. This variant has been named mask-like metastasis 50 (Fig.…”

Section: Metastatic Mammary Carcinoma Of the Eyelid With Histiocytoidmentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

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224

104

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Skin metastases occur in 0.6%-10.4% of all patients with cancer and represent 2% of all skin tumors. Skin metastases from visceral malignancies are important for dermatologists and dermatopathologists because of their variable clinical appearance and presentation, frequent delay and failure in their diagnosis, relative proportion of different internal malignancies metastasizing to the skin, and impact on morbidity, prognosis, and treatment. Another factor to take into account is that cutaneous metastasis may be the first sign of clinically silent visceral cancer. The relative frequencies of metastatic skin disease tend to correlate with the frequency of the different types of primary cancer in each sex. Thus, women with skin metastases have the following distribution in decreasing order of frequency of primary malignancies: breast, ovary, oral cavity, lung, and large intestine. In men, the distribution is as follows: lung, large intestine, oral cavity, kidney, breast, esophagus, pancreas, stomach, and liver. A wide morphologic spectrum of clinical appearances has been described in cutaneous metastases. This variable clinical morphology included nodules, papules, plaques, tumors, and ulcers. From a histopathologic point of view, there are 4 main morphologic patterns of cutaneous metastases involving the dermis, namely, nodular, infiltrative, diffuse, and intravascular. Generally, cutaneous metastases herald a poor prognosis. The average survival time of patients with skin metastases is a few months. In this article, we review the clinicopathologic and immunohistochemical characteristics of cutaneous metastases from internal malignancies, classify the most common cutaneous metastases, and identify studies that may assist in diagnosing the origin of a cutaneous metastasis.

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“…11 The histopathologic features of primary signet-ring cell or histiocytoid carcinoma of the eyelid may be indistinguishable from those of internal signet-ring cell or histiocytoid malignancies metastatic to the lids. In female patients, signet-ring cell or histiocytoid mammary carcinoma, a rare variant of lobular mammary carcinoma, is the most common origin from metastatic eyelid carcinoma, 24,34,43,71 although signet-ring cell carcinomas from the stomach or intestinal tract have also been described as metastasizing to the eyelid. 34,43 Metastatic eyelid involvement may be the first sign of internal malignancy and the neoplasm may be misinterpreted as a primary eyelid carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…In female patients, signet-ring cell or histiocytoid mammary carcinoma, a rare variant of lobular mammary carcinoma, is the most common origin from metastatic eyelid carcinoma, 24,34,43,71 although signet-ring cell carcinomas from the stomach or intestinal tract have also been described as metastasizing to the eyelid. 34,43 Metastatic eyelid involvement may be the first sign of internal malignancy and the neoplasm may be misinterpreted as a primary eyelid carcinoma. 2,42 Therefore, a careful clinicopathologic correlation with systemic workup to rule out another primary internal malignancy should be made before a diagnosis of primary signet-ring cell carcinoma of the eyelid can be established.…”

Section: Discussionmentioning

confidence: 99%

Spindle Cell Thymomas (WHO Type A) With Prominent Papillary and Pseudopapillary Features

Kalhor

Suster

Moran

2011

American Journal of Surgical Pathology

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Ten cases of spindle cell thymomas with prominent papillary and pseudopapillary features were presented. The patients were 7 men and 3 women between the ages of 47 and 75 years. Clinically, 3 patients were asymptomatic, 1 patient presented with chest pain, 4 patients with shortness of breath, and 1 patient with a history of pulmonary tuberculosis. One case was found during an autopsy procedure. Nine patients underwent complete surgical resection of their mediastinal tumors, which varied in size from 4 to 9 cm in greatest diameter. Histologically, all tumors showed a spindle cell appearance (WHO type A) with elongated nuclei and inconspicuous nucleoli. Scattered lymphocytes were present admixed with the spindle cellular proliferation. In addition, all tumors showed prominent areas of papillary and pseudopapillary features, which varied in size and type. In some cases, prominent areas of hyalinization were also present, whereas in other cases the papillary-like changes were composed of edematous projections, which imparted these tumors a unique morphologic growth pattern. Three tumors were encapsulated, whereas 7 other tumors were invasive. Immunohistochemical studies for keratin CAM5.2 and keratin 5/6 showed strong positive reaction, whereas other stains including CEA, calretinin, CD-31, and thyroglobulin were negative. Follow-up information showed that 2 patients are alive and well, whereas 3 patients have died. No follow-up information was obtained in 4 patients. The current morphologic appearance has not been previously emphasized in thymomas, which is important to recognize to avoid misdiagnosis with other mediastinal neoplasms.

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Mask-Like Metastasis: Report of 2 Cases of 4 Eyelid Metastases and Review of the Literature

Cited by 19 publications

References 16 publications

Monocle and mask‐like metastasis: two cases of eyelid metastasis from breast carcinoma – role of isotopic phenomenon?

Monocle and mask‐like metastasis: two cases of eyelid metastasis from breast carcinoma – role of isotopic phenomenon?

Cutaneous Metastases From Internal Malignancies

Spindle Cell Thymomas (WHO Type A) With Prominent Papillary and Pseudopapillary Features

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