Maskless photolithography using UV LEDs

Guijt, Rosanne M.; Breadmore, Michael C.

doi:10.1039/b800465j

Cited by 51 publications

(30 citation statements)

References 14 publications

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“…[ 59 ] Rapid microfl uidic chip prototypes are produced with maskless photolithography using a liquid crystal display projector to pattern photoresist [ 60 ] and direct lithographic patterning of photoresist using a collimated and focused ultraviolet light emitting diode. [ 61 ] Cleanroom environments for microfabrication are not always available. For this reason, several approaches have been proposed to fabricate microfl uidic devices using minimal infrastructure for research prototyping.…”

Section: Progress Reportmentioning

confidence: 99%

Microfluidic Chips for Point‐of‐Care Immunodiagnostics

2011

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We might be at the turning point where research in microfluidics undertaken in academia and industrial research laboratories, and substantially sponsored by public grants, may provide a range of portable and networked diagnostic devices. In this Progress Report, an overview on microfluidic devices that may become the next generation of point-of-care (POC) diagnostics is provided. First, we describe gaps and opportunities in medical diagnostics and how microfluidics can address these gaps using the example of immunodiagnostics. Next, we conceptualize how different technologies are converging into working microfluidic POC diagnostics devices. Technologies are explained from the perspective of sample interaction with components of a device. Specifically, we detail materials, surface treatment, sample processing, microfluidic elements (such as valves, pumps, and mixers), receptors, and analytes in the light of various biosensing concepts. Finally, we discuss the integration of components into accurate and reliable devices.

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Section: Progress Reportmentioning

confidence: 99%

Microfluidic Chips for Point‐of‐Care Immunodiagnostics

2011

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“…UV LEDs have been used as a substitute exposure source for direct writing lithography (Guijt and Breadmore 2008), however, this approach is not optimal for the design of microfluidic devices with complex structural and functional features, and still costs at least US$6000. Another method is patterning paper-based microfluidic devices by using a UV lamp, but the features are limited by more than 200 lm wide (Martinez et al 2008).…”

Section: Introductionmentioning

confidence: 99%

A simple photolithography method for microfluidic device fabrication using sunlight as UV source

Jiang

Pan

et al. 2010

Microfluid Nanofluid

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A straightforward method for microfluidic devices fabrication using sunlight as the ultraviolet (UV) source is established in this work. This method is based on photolithography, but obviates the need for specialized UV exposure facility. Substrates coated with photoresist were placed directly under sun in a perpendicular direction to the sunlight for exposure. Exposure conditions were optimized for patterning features with different kinds of photoresist, photoresist of different thicknesses and dimensions. Exposure time can be adjusted to obtain designed features on a mask with good lateral structure according to the energy measured by UV meter (with a constant intensity of UV in sunlight). Masters produced under optimum exposure conditions were used for the fabrication of several microfluidic devices with different materials, structures, or functions. Resultant devices were shown eminently suitable for microfluidic applications such as electrophoretic separation, multiple gradient generator, and pneumatic valve-based cell culture. This photolithographic method is simple, low cost, easy to operate, and environmental friendly. Especially, the masters can be obtained in parallel simultaneously, which is suitable for chip fabrication for mass production. It is also more attractive for the laboratories, in which the support for photolithographic facility is not available.

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“…5,6) Then, maskless lithography appeared, where patterns were created by light reflection either from analog or digital mirrors. [7][8][9][10] Direct synthesis of DNA on a platform is important because today real-time PCR and DNA microarrays are the most commonly used molecular diagnostics tools for in-vitro diagnosis (IVD). With the real-time PCR, one can determine the amount of viral particles in blood and quantitatively analyze the number of DNA in samples.…”

Section: Introductionmentioning

confidence: 99%

A simple and cost-effective molecular diagnostic system and DNA probes synthesized by light emitting diode photolithography

Oleksandrov¹,

Kwon²,

Lee³

et al. 2014

OPT REV

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This work introduces a novel chip to be used in the future as a simple and cost-effective method for creating DNA arrays using light emission diode (LED) photolithography. The DNA chip platform contains 24 independent reaction sites, which allows for the testing of a corresponding amount of patients' samples in hospital. An array of commercial UV LEDs and lens systems was combined with a microfluidic flow system to provide patterning of 24 individual reaction sites, each with 64 independent probes. Using the LED array instead of conventional laser exposure systems or micro-mirror systems significantly reduces the cost of equipment. The microfluidic system together with microfluidic flow cells drastically reduces the amount of used reagents, which is important due to the high cost of commercial reagents. The DNA synthesis efficiency was verified by fluorescence labeling and conventional hybridization.

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Maskless photolithography using UV LEDs

Cited by 51 publications

References 14 publications

Microfluidic Chips for Point‐of‐Care Immunodiagnostics

Microfluidic Chips for Point‐of‐Care Immunodiagnostics

A simple photolithography method for microfluidic device fabrication using sunlight as UV source

A simple and cost-effective molecular diagnostic system and DNA probes synthesized by light emitting diode photolithography

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