Maslinic Acid Protects Against Isoproterenol-Induced Cardiotoxicity in Albino Wistar Rats

Abstract

The present study aimed to evaluate the protective effect of maslinic acid (MA) on body weight, heart weight, lipids, lipoproteins, lipid peroxidation (LPO), cardiac marker enzymes, and paraoxonase (PON) in normal control and isoproterenol (ISO)-induced myocardial infarcted albino Wistar rats. After treatment with MA (15 mg/kg) for 7 days, myocardial infarction was induced by subcutaneous injection of ISO (85 mg/kg) for two consecutive days. ISO caused a considerable decrease in body weight and increased the heart weight. The concentrations of total cholesterol, triglycerides, very low-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol were higher, whereas that of high-density lipoprotein-cholesterol was lower, in the serum of ISO-administered rats. The activities of the cardiac marker enzymes creatine kinase, alanine transaminase, aspartate transaminase, and γ-glutamyl transferase and levels of malondialdehyde were elevated in the serum of ISO-treated rats. ISO-administered rats also exhibited a decline in the activity of PON. Pretreatment of rats with MA reduced the effects of ISO on all parameters tested. This is the first report of the protective effect of MA on ISO-induced cardiotoxicity and of an association between PON status and MA supplementation. The observed cardioprotective effects may be due to the antihyperlipidemic potential of MA, inhibition of LPO, and antioxidant activity.

Maslinic Acid-Enriched Diet Decreases Intestinal Tumorigenesis in ApcMin/+ Mice through Transcriptomic and Metabolomic Reprogramming

“…It is noteworthy that this observation may be involved in the loss of weight detected in Apc Min/+ mice after MA treatment. Moreover, our results are in agreement with previous studies describing antihyperlipidemic [51] and antihyperglycemic [14] activities for MA. Given that accumulating evidence suggests that obesity [52] and hyperglycemia [53] are associated with increased risk of colorectal cancer, the metabolic changes induced by MA treatment are potentiating its chemoprotective effect in Apc Min/+ mice.…”

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

“…In addition to the abovementioned, multiple other extracts and traditional formulations have been investigated in ISP‐induced cardiotoxicity with promising protective effects (Wong et al, ). Some of these include Rhus tripartita extract (Shahat et al, ), maslinic acid (Hussain Shaik et al, ), isorhapontigenin (Abbas, ), sodium tanshinone IIA sulphonate (Wei et al, ), S‐allyl cysteine sulfoxide (Sangeetha & Quine, ), policosanol (Noa, Herrera, Magraner, & Mas, ), alatamine (Zhao et al, ), timosaponin B II (Deng et al, ), vanillic acid (Prince, Rajakumar, & Dhanasekar, ), icariin (Pan, Wang, Yang, Kong, & Wang, ), danshensu (Li et al, ), Muntingia calabura (Nivethetha, Jayasri, & Brindha, ), and Crataegus oxycantha (Jayalakshmi, Thirupurasundari, & Devaraj, ). A diagrammatic presentation of the main pathways inhibited by various phytoconstituents is presented in Figure .…”

Protective role of poly(lactic‐co‐glycolic) acid nanoparticle loaded with resveratrol against isoproterenol‐induced myocardial infarction

“…RSV protects dopaminergic neurons from LPS‐induced neurotoxicity in mesencephalic neuron–glia cultures . RSV protects primary cultured astrocytes from in vitro ischemia‐induced damage . These data suggest that RSV increases NO production from eNOS to exert the antiapoptotic effect of NO, and thus contributes to RSV PLGA NPs cardioprotective effect.…”