Getting along (i.e. to be liked) and getting ahead (i.e. to be popular) are two fundamental psychological motives that have important consequences for adolescents' well-being. Especially antisocial behavioural tendencies, which are less well covered by the Big Five than by the HEXACO model, have been shown to differentially predict likeability and popularity. In this study, possible differential relations between personality and likeability and popularity were investigated using the HEXACO Simplified Personality Inventory and sociometric measures of likeability and popularity among 552 (12 to 14 years old) adolescents. Results showed that agreeableness was the most important likeability predictor, whereas extraversion (positive), openness to experience, honesty-humility, and agreeableness (all three negative) were the most important popularity predictors. Facet-level analyses revealed that selected HEXACO facets (greed avoidance, fearfulness, social boldness, gentleness, prudence, perfectionism, aesthetic appreciation, and altruism) most strongly-and in opposite directions-differentiated in the prediction of likeability and popularity. Furthermore, none of the expected interactions but several masking and cancellation effects were observed. The results, which are also discussed in light of interpersonal circumplex, resource control strategies, hierarchical differentiation, and socioanalytic frameworks, suggest that-among early adolescents-differential personality predictors may make it difficult to both get along and get ahead.