Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata)

Luo, Jian; Chuang, T.; Cheung, Jeanne; Quan, Josephine; Tsai, Joyce; Sullivan, Cynthia S.; Hector, Richard F.; Reed, Michael J.; Meszaros, Karl; King, Steven R.; Carlson, Thomas J.; Reaven, Gerald M.

doi:10.1016/s0014-2999(98)00139-3

Cited by 71 publications

(42 citation statements)

References 4 publications

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“…NDGA is a pure compound isolated from the creosote bush, Larrea tridentate. 59 It significantly reduces plasma glucose and triglyceride concentrations in rats. 59,60 It also suppresses A␤-induced accumulation of reactive oxygen species.…”

Section: Phenolic Compounds Prevent Ad Pathology 2561mentioning

confidence: 97%

“…59 It significantly reduces plasma glucose and triglyceride concentrations in rats. 59,60 It also suppresses A␤-induced accumulation of reactive oxygen species. 61 In a recent study 26 of A␤ fibril formation in vitro, NDGA inhibited oligomerization but did not affect fibrillization, which was contrary to the present results.…”

Section: Phenolic Compounds Prevent Ad Pathology 2561mentioning

confidence: 97%

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Phenolic Compounds Prevent Alzheimer’s Pathology through Different Effects on the Amyloid-β Aggregation Pathway

Hamaguchi

Ono

Murase

et al. 2009

The American Journal of Pathology

379

270

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Inhibition of amyloid-␤ (A␤) aggregation is an attractive therapeutic strategy for Alzheimer's disease (AD). Certain phenolic compounds have been reported to have anti-A␤ aggregation effects in vitro.This study systematically investigated the effects of phenolic compounds on AD model transgenic mice (Tg2576). Mice were fed five phenolic compounds (curcumin, ferulic acid, myricetin, nordihydroguaiaretic acid (NDGA), and rosmarinic acid (RA)) for 10 months from the age of 5 months. Immunohistochemically, in both the NDGA-and RA-treated groups, A␤ deposition was significantly decreased in the brain (P < 0.05). In the RA-treated group , the level of Trisbuffered saline (TBS)-soluble A␤ monomers was increased (P < 0.01), whereas that of oligomers, as probed with the A11 antibody (A11-positive oligomers), was decreased (P < 0.001). However, in the NDGA-treated group, the abundance of A11-positive oligomers was increased (P < 0.05) without any change in the levels of TBS-soluble or TBS-insoluble A␤. In the curcumin-and myricetin-treated groups, changes in the A␤ profile were similar to those in the RA-treated group, but A␤ plaque deposition was not significantly decreased. In the ferulic acid-treated group, there was no significant difference in the A␤ profile. These results showed that oral administration of phenolic compounds prevented the development of AD pathology by affecting different A␤ aggregation pathways in vivo. Clinical trials with these compounds are necessary to confirm the anti-AD effects and safety in humans. Alzheimer's disease (AD) is the most common form of dementia, resulting in deterioration of cognitive function and behavioral changes.1 One of the pathological hallmarks of AD is extracellular deposits of aggregated amyloid-␤ protein (A␤) in the brain parenchyma (senile plaques) and cerebral blood vessels (cerebral amyloid angiopathy (CAA)).1 Deposition of high levels of fibrillar A␤ in the AD brain is associated with loss of synapses, impairment of neuronal functions, and loss of neurons. 2-5A␤ was sequenced from meningeal vessels and senile plaques of AD patients and individuals with Down's syndrome.6 -8 The subsequent cloning of the gene encoding the ␤-amyloid precursor protein and its localization to chromosome 21, 9 -12 coupled with the earlier recognition that trisomy 21 (Down's syndrome) invariably leads to the neuropathology of AD, 13 set the stage for the proposal that A␤ accumulation is the primary event in AD pathogenesis. In addition, certain mutations associated with familial AD have been identified within or near the A␤ region of the coding sequence of gene of the amyloid precursor proteins, 14,15 presenilin-1 and presenilin-2, 16 which alter amyloid precursor protein metabolism through a direct effect on ␥-secretase. 17,18 These findings set the stage for the proposal that A␤ aggregation is the primary event in AD pathogenesis and leading to the proposal that anti-A␤ aggregation is a strategy for AD therapy.

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Section: Phenolic Compounds Prevent Ad Pathology 2561mentioning

confidence: 97%

Section: Phenolic Compounds Prevent Ad Pathology 2561mentioning

confidence: 97%

Phenolic Compounds Prevent Alzheimer’s Pathology through Different Effects on the Amyloid-β Aggregation Pathway

Hamaguchi

Ono

Murase

et al. 2009

The American Journal of Pathology

379

270

View full text Add to dashboard Cite

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“…In recent years, research has focusing on search of naturally occurring substances capable of acting as alternative antimicrobials and antioxidants in minimally processed fruits and vegetables (Saucedo-Pompa et al, 2009), in order to reduce the negative effects of maturation process, improving quality of Tarbush (Flourensia cernua) plant is widely distributed in the semiarid region of Northern Mexico and Southern United States of Amerca, which is currently only used empirically for infusions preparation to treat some diseases or ailments for the rural population in Mexico, particularly (Belmares, Garza, Rodríuez, Contreras-Esquivel, & Aguilar, 2009). Tarbush extracts or constituents have reported to possess antioxidant (Abou-Gazar, Bedir, Takamatsu, Ferreira, & Khan, 2004), anti-HIV (Gnabre, Ito, Ma, & Huang, 1996), antimicrobial, enzyme inhibitory, antitumor (MacRae & Towers, 1984), and antihyperglycemic (Luo et al, 1998) activities. Tarbush leaves contain substantial levels of polyphenolic compounds (Hyder, Fredrickson, Estell, Lucero, & Remmenga, 2005), which may have digestive properties (Belmares et al, 2009) and fungicide activity against phytopathogenic fungi such as Rhizoctonia solani, Phytophthora infestans (Gamboa-Alvarado, Herná ndezCastillo, Guerrero-Rodríguez, Sá nchez-Arizpe, & Lira- Saldivar, 2003), and Colletotrichum spp.…”

Section: Introductionmentioning

confidence: 99%

Edible candelilla wax coating with fermented extract of tarbush improves the shelf life and quality of apples

León-Zapata

Sáenz‐Galindo

Rojas

et al. 2015

Food Packaging and Shelf Life

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“…In addition, improved oral glucose tolerance and the ability of insulin to lower plasma glucose concentrations were also raised. 88 Tribulus terrestris: A lead structure, N-transcoumaroyl tyramine (24) was isolated from T. terrestris extracts exhibited anti-diabetic effect via significant inhibition of α-glucosidase enzyme. 89 …”

Section: Zygophyllaceaementioning

confidence: 99%

A Review on Anti-diabetic Plants

Qais

Jahan

Shajib

2018

Dhaka Univ. J. Pharm. Sci

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Diabetes mellitus is a common metabolic disorder whose prevalence is rapidly increasing all over the world. According to WHO, diabetes will be the seventh leading cause of death in 2030. Since long back, plants have been used to heal or combat illness and are the source of many modern medicines. In view of the above aspects, the present review provides information about the antidiabetic plants, available through literature source from various database. From the present study it is evident that most of the plants having anti-diabetic properties belong to the family Moraceae, Cucurbitaceae, Liliaceae, Anacardiaceae, Myrtaceae, Fabaceae, Solanaceae, Asteraceae and many others. The hypoglycemic activities are contained in different parts of these plants like leaf, rhizomes, fruits, bark, seeds or other parts which differ from species to species. It is also evident from this review that the mode of action and dosage of administration differs from plant to plant.

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Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata)

Cited by 71 publications

References 4 publications

Phenolic Compounds Prevent Alzheimer’s Pathology through Different Effects on the Amyloid-β Aggregation Pathway

Phenolic Compounds Prevent Alzheimer’s Pathology through Different Effects on the Amyloid-β Aggregation Pathway

Edible candelilla wax coating with fermented extract of tarbush improves the shelf life and quality of apples

A Review on Anti-diabetic Plants

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