2023
DOI: 10.1186/s40478-023-01583-0
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Mass cytometric analysis of the immune cell landscape after traumatic brain injury elucidates the role of complement and complement receptors in neurologic outcomes

Abstract: Following traumatic brain injury (TBI), a neuroinflammatory response can persist for years and contribute to the development of chronic neurological manifestations. Complement plays a central role in post-TBI neuroinflammation, and C3 opsonins and the anaphylatoxins (C3a and C5a) have been implicated in promoting secondary injury. We used single cell mass cytometry to characterize the immune cell landscape of the brain at different time points after TBI. To specifically investigate how complement shapes the po… Show more

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Cited by 2 publications
(3 citation statements)
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“…In this regard, microglia from vehicle treated mice exhibit decreased ramification and increased numbers in the contralateral dLGN, which is suggestive of increased phagocytic capacity [ 15 ]. Previous work by our group has shown that microglia and infiltrating immune cells increase shortly after CCI, with numbers peaking around 7 days after injury [ 36 ]. Toutonji et al [ 36 ] showed that complement inhibition results in a significant decrease in the total number of microglia relative to vehicle by day 7 with a continuing decrease until day 28.…”
Section: Resultsmentioning
confidence: 99%
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“…In this regard, microglia from vehicle treated mice exhibit decreased ramification and increased numbers in the contralateral dLGN, which is suggestive of increased phagocytic capacity [ 15 ]. Previous work by our group has shown that microglia and infiltrating immune cells increase shortly after CCI, with numbers peaking around 7 days after injury [ 36 ]. Toutonji et al [ 36 ] showed that complement inhibition results in a significant decrease in the total number of microglia relative to vehicle by day 7 with a continuing decrease until day 28.…”
Section: Resultsmentioning
confidence: 99%
“…Previous work by our group has shown that microglia and infiltrating immune cells increase shortly after CCI, with numbers peaking around 7 days after injury [ 36 ]. Toutonji et al [ 36 ] showed that complement inhibition results in a significant decrease in the total number of microglia relative to vehicle by day 7 with a continuing decrease until day 28. The level of microgliosis decreases to that of naïve mice as early as 28 days after injury.…”
Section: Resultsmentioning
confidence: 99%
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