2023
DOI: 10.1016/j.cmi.2022.10.022
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Mass drug administration of azithromycin: an analysis

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Cited by 4 publications
(2 citation statements)
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“…Note that in statistical analysis of adverse outcomes such as resistance reported here, statistical conservatism may de-emphasize potentially important safety indicators. The results of this trial add to the growing body of evidence that supports regular antibiotic resistance surveillance in the setting of azithromycin MDA [ 24 26 ].…”
Section: Discussionmentioning
confidence: 90%
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“…Note that in statistical analysis of adverse outcomes such as resistance reported here, statistical conservatism may de-emphasize potentially important safety indicators. The results of this trial add to the growing body of evidence that supports regular antibiotic resistance surveillance in the setting of azithromycin MDA [ 24 26 ].…”
Section: Discussionmentioning
confidence: 90%
“…From a surveillance standpoint for azithromycin MDA for either trachoma or childhood mortality, this current study is one of the largest trials attempting to comprehensively characterize antimicrobial resistance in a randomized controlled trial setting [ 7 , 24 ]. While phenotypic analysis may improve the mechanistic understanding at the individual bacteria level or at the species level, the hurdles associated with sample handling in the field, maintaining cold-chains across Niger, and the sheer number of samples and communities involved make such an analysis more difficult.…”
Section: Discussionmentioning
confidence: 99%