Mass fragmentographic determination of prostaglandin F2α in human and rabbit urine

Sjöquist, Birgitta; Oliw, Ernst H.; Lundén, Inger; Änggård, Erik

doi:10.1016/s0378-4347(00)81162-7

Cited by 8 publications

(1 citation statement)

References 14 publications

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“…The [M -Me 3 SiOH] +• ions and tetradeuterio analogs as internal standards were involved in the measurement. 94,95 Quantitative analysis of some similar prostaglandins can be accomplished by GC/EI-MS in a SIM mode by applying other fragment ions. For example, ions [M -C 5 H 11 -Me 3 SiOH] + (loss of pentyl radical as shown in the above structure) appeared to be more suitable for simultaneous determination of prostaglandins F 2α , E 1α , E 2α and 19-hydroxy-F 2α and -E 2α in the semen of fertile men.…”

Section: Mixed Derivatives Of Hydroxy Acidsmentioning

confidence: 99%

Derivatization in Mass Spectrometry—6. Formation of Mixed Derivatives of Polyfunctional Compounds

Заикин

Halket

2005

Eur J Mass Spectrom (Chichester)

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The review describes chemical transformations of multifunctional compounds (amino acids and peptides, amino alcohols, amino thiols, hydroxy acids, oxo acids, oxo alcohols, compounds containing simultaneously three or more different groups etc.) by using step-wise or one-step modification or protection of functional groups. Some chemical aspects of mixed derivatization performed for improving the physical-chemical properties and mass spectral characteristics are discussed. Application of mixed derivatization to qualitative and quantitative analysis of various multifunctional compounds mainly in biological fluids and other matrices by gas chromatography/mass spectrometry in electron ionization, chemical ionization, negative-ion chemical ionization and selected ion monitoring modes is considered.

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Section: Mixed Derivatives Of Hydroxy Acidsmentioning

confidence: 99%