Abstract:Single‐cell MALDI mass spectrometry imaging (MSI) of lipids and metabolites >200 Da has recently come to the forefront of biomedical research and chemical biology. However, cell‐targeting and metabolome‐preserving methods for analysis of low mass, hydrophilic metabolites (<200 Da) in large cell populations are lacking. Here, the PRISM‐MS (PRescan Imaging for Small Molecule – Mass Spectrometry) mass‐guided MSI workflow is presented, which enables space‐efficient single cell lipid and metabolite analysis. … Show more
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