Mass production of thin-walled hollow optical fibers enables disposable optofluidic laser immunosensors

Yang, Xi; Luo, Yanhua; Liu, Yiling; Gong, Chen; Wang, Yanqiong; Rao, Yunjiang; Peng, Gang‐Ding; Gong, Yuan

doi:10.1039/c9lc01216h

Cited by 40 publications

(33 citation statements)

References 44 publications

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“…In 2020, Yang et al demonstrated a disposable FOFL immunosensor based on HOF with a small variation of 3.3%. [2] The disposable manner allows a number of tests, enabling the statistical analysis of laser emission and protein concentrations. Similar properties were also demonstrated by using the telecom optical fibers and the twin-hole MOF.…”

Section: Disposable Testmentioning

confidence: 99%

“…It could rely on the standing wave in a DOI: 10.1002/lpor.202100171 Fabry-Pérot (FP) cavity or traveling wave in a microring resonator, which can be performed by optical fibers to achieve optical resonance in the axial, angular, or radial directions (Figure 1b). [1][2][3][4] The aqueous gain medium incorporated with the microcavity provides the population inversion and optical amplification for lasing. Many types of materials, from laser dyes, luminescent nanomaterials like quantum dots (QDs), perovskite materials, to bioluminescent materials such as fluorescent proteins can be employed as gain medium.…”

Section: Introductionmentioning

confidence: 99%

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Fiber Optofluidic Microlasers: Structures, Characteristics, and Applications

Yang

Gong

Zhang

et al. 2021

Laser & Photonics Reviews

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Herein, recent progress in fiber optofluidic lasers and their applications in biochemical detection are reviewed. The unique properties of optical fibers are introduced for the development of optofluidic microlasers, including high quality factor, small mode volume, high aspect ratio, high reproducibility, and low cost. Optical fiber microresonators based on Fabry-Pérot cavity, microring resonator or photonic bandgap cavity are highlighted to provide optical feedback for optofluidic lasing. For applications, the capability of fiber optofluidic lasers is emphasized to perform biochemical analysis with ultrahigh sensitivity, fast response, high throughput, and disposable optical biodetection. The challenges and prospects for fiber optofluidic lasers are also discussed.

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Section: Disposable Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fiber Optofluidic Microlasers: Structures, Characteristics, and Applications

Yang

Gong

Zhang

et al. 2021

Laser & Photonics Reviews

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“…is device was based on thin-wall hollow optical fibers (HOFs) which allowed the distribution of the identical laser microring resonators along the fibers. e reproducibility was validated with a low coefficient of variation of 3.3% [111].…”

Section: Optofluidic System In Immunoassaysmentioning

confidence: 99%

Application of Microfluidics in Immunoassay: Recent Advancements

Shi

Peng

Yang

et al. 2021

Journal of Healthcare Engineering

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In recent years, point-of-care testing has played an important role in immunoassay, biochemical analysis, and molecular diagnosis, especially in low-resource settings. Among various point-of-care-testing platforms, microfluidic chips have many outstanding advantages. Microfluidic chip applies the technology of miniaturizing conventional laboratory which enables the whole biochemical process including reagent loading, reaction, separation, and detection on the microchip. As a result, microfluidic platform has become a hotspot of research in the fields of food safety, health care, and environmental monitoring in the past few decades. Here, the state-of-the-art application of microfluidics in immunoassay in the past decade will be reviewed. According to different driving forces of fluid, microfluidic platform is divided into two parts: passive manipulation and active manipulation. In passive manipulation, we focus on the capillary-driven microfluidics, while in active manipulation, we introduce pressure microfluidics, centrifugal microfluidics, electric microfluidics, optofluidics, magnetic microfluidics, and digital microfluidics. Additionally, within the introduction of each platform, innovation of the methods used and their corresponding performance improvement will be discussed. Ultimately, the shortcomings of different platforms and approaches for improvement will be proposed.

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“…The conformational change of DNA Holliday junction leads to the variation of the FRET ratio, which in turn corresponds to the Mg 2+ concentration at a much higher sensitivity with laser-based detection than that of traditional FRET detection. Yang et al [116] have demonstrated disposable FOFLs for protein detection [Fig. 6(b)].…”

Section: Biomolecular Analysismentioning

confidence: 99%

“…Fig. 6 FOFL for application in biomolecular analysis application of fiber optofluidic laser: (a) detection of the conformational change in a Holliday junction upon addition of Mg 2+ [115], (b) disposable FOFL for the detection of protein [116], (c) array of FOFL for colorimetric detection [59], and (d) wavelength-modulated random laser with the Ag nanoparticles as scatterers [120].…”

Section: Biomolecular Analysismentioning

confidence: 99%

Recent Progress in Fiber Optofluidic Lasing and Sensing

et al. 2021

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Fiber optofluidic laser (FOFL) integrates optical fiber microcavity and microfluidic channel and provides many unique advantages for sensing applications. FOFLs not only inherit the advantages of lasers such as high sensitivity, high signal-to-noise ratio, and narrow linewidth, but also hold the unique features of optical fiber, including ease of integration, high repeatability, and low cost. With the development of new fiber structures and fabrication technologies, FOFLs become an important branch of optical fiber sensors, especially for application in biochemical detection. In this paper, the recent progress on FOFL is reviewed. We focuse mainly on the optical fiber resonators, gain medium, and the emerging sensing applications. The prospects for FOFL are also discussed. We believe that the FOFL sensor provides a promising technology for biomedical analysis and environmental monitoring.

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Mass production of thin-walled hollow optical fibers enables disposable optofluidic laser immunosensors

Abstract: It is challenging to develop disposable optical biosensors due to the high cost and poor reproducibility. Here we report the disposable laser-based immunosensor enabled by mass-produced hollow optical fiber.

Cited by 40 publications

References 44 publications

Fiber Optofluidic Microlasers: Structures, Characteristics, and Applications

Fiber Optofluidic Microlasers: Structures, Characteristics, and Applications

Application of Microfluidics in Immunoassay: Recent Advancements

Recent Progress in Fiber Optofluidic Lasing and Sensing

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