Mass fainting Illness (MFI) has occurred repeatedly for years in factory settings in Cambodia. This study examines factors related to MFI, such as worker 'characteristics, organizational, psychosocial-work, and non-work factors, among Cambodian-factory workers. A factory-based cross-sectional study was conducted among 740 workers in October 2017 using structured questionnaires. Female workers and workers with longer duration of work had a higher-risk of MFI, but a lower-risk for those working in factory before and those absent due to occupational accident. Organizational determinants, such as workers employed in a shorter fixedterm, and those performing repetitive task and a low-skill work were significantly at a higher-risk of MFI, but a lower-risk for those performing a night/evening shift work. The study also showed that Psychosocial-work complaints, workers with less influence on their choice of co-workers, perceived a high temperature at work, and have little opportunity to work at their best had a lower-risk, but a higher-risk for those who lost jobs and those traveling by bicycles/walking to work. Overall, worker characteristics, organizational determinants, psychosocial-work complaints, and external-work factors were independent predictors explaining 31.8% of the overall-MFI prevalence.