Mass-selection of reactant ions for chemical ionization in quadrupole ion trap and triple quadrupole mass spectrometers

Berberich, David W.; Hail, Mark E.; Johnson, Jodie V.; Yost, Richard A.

doi:10.1016/0168-1176(89)80063-1

Cited by 34 publications

(9 citation statements)

References 23 publications

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“…In general, and until the reagent ion population is depleted, increasing the CI reaction time will increase analyte ion intensity; if storage is performed near a nonlinear resonance line, however, a competing pro- mass-selected CI using czHt of methane at an RF level corresponding to a nonlinear resonance for mI z 29 can result in ionization of the analyte by not only czHt (mlz 29), but also by C 3Ht (mlz 41). The conversion of C 2Ht, which favors proton transfer, to C 3 H t , which favors hydride abstraction [39], can alter the resulting CI mass spectrum.…”

Section: Inspection Ofmentioning

confidence: 99%

Nonlinear resonance effects during ion storage in a quadrupole ion trap

Eades

Johnson

Yost

1993

J. Am. Soc. Mass Spectrom.

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Contributions of higher-order fields to the quadrupolar storage field produce nonlinear resonances in the quadrupole ion trap. Storing ions with secular frequencies corresponding to these nonlinear resonances allows absorption of power from the higher-order fields. This results in increased axial and radial amplitudes which can cause ion ejection and collision-induced dissociation (CID). Experiments employing long storage times and/or high ion populations, such as chemical ionization, ion-molecule reaction studies, and resonance excitation CID, can be particularly susceptible to nonlinear resonance effects. The effects of higher-order fields on stored ions are presented and the influence of instrumental parameters such as radiofrequency and direct current voltage (qZ and az values), ion population, and storage time are discussed.

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Section: Inspection Ofmentioning

confidence: 99%

Nonlinear resonance effects during ion storage in a quadrupole ion trap

Eades

Johnson

Yost

1993

J. Am. Soc. Mass Spectrom.

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“…2,7 A [M -H] + ion was also produced particularly under C 3 H 5 + /CI (hydride-ion affinity (HIA) of C 3 H 5 + being 1070 kJ mol -1 ). 7 In the latter conditions, the spectrum exhibited an abundant ion (base peak) at m/z 85 presumably of acylium structure. Thus, this ion most probably originates from [M -H] + in a similar way to that mentioned above for NO + (from N 2 O)/CI.…”

Section: Mass-selected Reagent Ion Chemical Ionization For the Locatimentioning

confidence: 97%

“…5,6 For instance, the QITMS can be used as a suitable device to achieve sensitive mass-selected reagent ion chemical ionization (CI). [7][8][9] The selection of a single reagent ion from complex plasma reactants greatly simplifies the resulting CI spectra by avoiding the formation of undesired product ions. On the other hand, such a procedure was also shown 7 to control the amount of energy transferred into the analytes during the ionization process thus influencing the degree of fragmentation of the initial molecular species.…”

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confidence: 99%

Mass‐selected reagent ion chemical ionization and multiple tandem mass spectrometry techniques in an ion trap mass spectrometer for structural analysis

Sharifi

Einhorn

1997

Rapid Commun. Mass Spectrom.

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Mass-selected reagent ion chemical ionization (CI) performed in an ion trap instrument is an efficient tool to investigate gas-phase ion reactivities and therefore to find out new and/or optimized applications for structural analysis. For instance, it was shown that the C 3 H 6 O + . (58 mass units) molecular ion originated from vinyl methyl ether (VME) should necessarily be used alone (i.e. unit-mass selected) to produce significant diagnostic-ions for double bond location in aliphatic alkenes. Regarding the assignment of epoxides, the previous NO + /CI method was adapted for an optimal use in the trap through isolation of NO + cation from N 2 O (instead of NO) plasma and production of the acylium diagnostic-ions via CID of [M -H]+ formed by NO + -induced hydride abstraction. New alkylation ion-products, e.g. RCH == O + -alk, were also found to characterize isomeric epoxides as a result of either an initial electrophilic addition of the C 2 H 5 + cation (with saturated epoxides) or a methyl-transfer from [VME]+ . (with α, -unsaturated epoxides). The multiple tandem mass spectrometry (MS n ) capabilities of the ion trap were essential to achieve reagent ion mass-selection, structural assignment of the diagnostic-ions, or to provide further selectivity.

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“…[3][4][5][6][7][8][9] Regarding applications, the high potential of this device to control ion/molecule reactions for structural determinations 10-12 including isomer differentiation [13][14][15] has also been demonstrated. An important advantage of the instrument lies in its capability to mass select a reagent ion from a plasma, [16][17][18] thus improving power of CI spectra for analysis and also facilitating investigations on specific ion reactivities.…”

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confidence: 99%

Combined Ion/Molecule Reactions and Multi-stage Tandem Mass Spectrometric Techniques in an Ion Trap Mass Spectrometer for the Characterization of Conjugated Ethylenic Epoxides. 1—Protonating Agents

Sharifi

Einhorn

1997

Rapid Commun. Mass Spectrom.

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The potential of the ion trap mass spectrometer to characterize isomeric long-chain conjugated mono-or diethylenic epoxides was investigated using the multi-stage tandem mass spectrometric (MS n ) facilities of the instrument. In the proposed approach, mass-selected reagent ions obtained from common protonating agents were prepared and allowed to react with the neutral epoxides for controlled reaction times. Positive-ion chemical ionization using the t-C 4 H 9 + ion (t-C 4 H 9 + /CI) and CH 5 + or C 2 H 5 + /CI were found to provide the most informative spectra (e.g. diagnostic ions generated by the decomposition of the MH + ion through competing pathways) as compared with NH 4 + /CI. An acylium diagnostic ion (A + ) stemming from the epoxide side was produced in both types of epoxides but its relative abundance was optimal using CH 5 + or C 2 H 5 + which are of low proton affinity. In the case of the dienes, an [M + A] + covalent adduction, probably resulting from a [4 + 2 + ] Diels-Alder cycloaddition process and thus specifically assigning such a system was generated (C 2 H 5 + /CI conditions). The MS n capabilities of the instrument were also used for the determination of the origin and structure of the diagnostic ions or for additional selectivity.

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Mass-selection of reactant ions for chemical ionization in quadrupole ion trap and triple quadrupole mass spectrometers

Cited by 34 publications

References 23 publications

Nonlinear resonance effects during ion storage in a quadrupole ion trap

Nonlinear resonance effects during ion storage in a quadrupole ion trap

Mass‐selected reagent ion chemical ionization and multiple tandem mass spectrometry techniques in an ion trap mass spectrometer for structural analysis

Combined Ion/Molecule Reactions and Multi-stage Tandem Mass Spectrometric Techniques in an Ion Trap Mass Spectrometer for the Characterization of Conjugated Ethylenic Epoxides. 1—Protonating Agents

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