Mass spectral fragmentation reactions of angiotensin-converting enzyme (ACE) inhibitors

Burinsky, David J.; Sides, Scott L.

doi:10.1016/j.jasms.2004.05.010

Cited by 21 publications

(14 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The product ion at m/z 227 was formed by the neutral loss of 2-amino-4-phenylbutanoic acid (179 Da). The CID spectrum of protonated lisinopril was similar to those obtained in previous studies (Burinsky and Sides, 2004;Pei et al, 2006).…”

Section: Identification Of the Unknown Impuritiessupporting

confidence: 84%

Characterization of impurities in the bulk drug lisinopril by liquid chromatography/ion trap spectrometry

Zhu

Wang

Sun

2008

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Two trace impurities in the bulk drug lisinopril were detected by means of high-performance liquid chromatography coupled with mass spectrometry (HPLC/MS) with a simple and sensitive method suitable for HPLC/MS n analysis. The fragmentation behavior of lisinopril and the impurities was investigated, and two unknown impurities were elucidated as 2-(6-amino-1-(1-carboxyethylamino)-1-oxohexan-2-ylamino)-4-phenylbutanoic acid and 6-amino-2-(1-carboxy-3-phenylpropylamino)-hexanoic acid on the basis of the multi-stage mass spectrometry and exact mass evidence. The proposed structures of the two unknown impurities were further confirmed by nuclear magnetic resonance (NMR) experiments after preparative isolation.

show abstract

Section: Identification Of the Unknown Impuritiessupporting

confidence: 84%

Characterization of impurities in the bulk drug lisinopril by liquid chromatography/ion trap spectrometry

Zhu

Wang

Sun

2008

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

show abstract

“…Spectroscopic [8][9][10], High Performance Liquid Chromatography (HPLC) [11][12][13], Thin Layer Chromatography (TLC) [14], Electrochemical [15][16][17] and mass spectrometry [18] methods for estimation of MOX alone or in combination with other drugs in pharmaceutical preparation have been reported. Hydrochlorothiazide alone or in combination with other drugs is estimated by HPLC [19][20][21][22][23][24][25][26][27][28][29], TLC-densitometry [30][31][32][33][34][35][36], capillary electrophoresis [37][38][39], electrochemical [40][41][42][43] and spectroscopic methods [44][45][46][47][48][49][50][51][52][53].…”

Section: Moexipril Hydrochloride (Mox) Is Chemically (3s)-2-[(2s)-2-{mentioning

confidence: 99%

Spectrophotometric and Chemometric Methods for Simultaneous Determination of Two Anti-Hypertensive Drugs in their Combined Dosage Form

Kelani¹,

Shalaby²,

El-Maamly³

et al. 2014

Pharm Anal Acta

View full text Add to dashboard Cite

In this study determination of Moexipril hydrochloride (MOX) and hydrochlorothiazide (HCT) were conducted by application of Spectrophotometric and Chemometric methods. Five different accurate, sensitive and reproducible methods were applied for the simultaneous determination of (MOX) and (HCT) in their bulk powder and pharmaceutical dosage form. The first method is the new absorbance subtraction (AS) method. The second method is the new amplitude modulation (AM) method. The third method is the new extended ratio subtraction (ERS) method coupled to ratio subtraction (RS) method. The fourth and fifth methods are multivariate calibration which includes Principal Component Regression (PCR) and Partial Least Squares (PLS). The suggested procedures were checked using laboratory prepared mixtures and were successfully applied for the analysis of their pharmaceutical preparations. The validity of the proposed methods was further assessed by applying the standard addition technique. The results obtained by applying the proposed methods were statistically analyzed and compared with a reported method.

show abstract

“…wts. and fragmentation scheme of the two wellknown degradation products of the drug [1,16], which were also listed in EP [15], viz., enalaprilat and diketopiperazine derivative, respectively. The m/z value of peak III matched to the mol.…”

Section: Lc-ms Studies On Forced Decomposition Samples Of Enalapril Mmentioning

confidence: 99%

“…5 gives the proposed scheme of fragmentation of the drug, and products I, II (enalaprilat) and III. The fragmentation pattern for drug and II is based on the behavior reported by Burinsky and Sides [16]. One major fragmentation route for these molecules includes elimination of ethylformate from enalapril and formic acid from II, to yield a common fragment of m/z 303, which does not seemingly fragments further.…”

Section: Lc-ms Studies On Forced Decomposition Samples Of Enalapril Mmentioning

confidence: 99%

Study of forced degradation behavior of enalapril maleate by LC and LC–MS and development of a validated stability-indicating assay method

Bhardwaj

Singh

2008

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

Mass spectral fragmentation reactions of angiotensin-converting enzyme (ACE) inhibitors

Cited by 21 publications

References 22 publications

Characterization of impurities in the bulk drug lisinopril by liquid chromatography/ion trap spectrometry

Characterization of impurities in the bulk drug lisinopril by liquid chromatography/ion trap spectrometry

Spectrophotometric and Chemometric Methods for Simultaneous Determination of Two Anti-Hypertensive Drugs in their Combined Dosage Form

Study of forced degradation behavior of enalapril maleate by LC and LC–MS and development of a validated stability-indicating assay method

Contact Info

Product

Resources

About